| Identification |
|---|
| HMDB Protein ID
| HMDBP14017 |
| Secondary Accession Numbers
| None |
| Name
| Trimeric autotransporter adhesin AtaA |
| Synonyms
|
- TAA AtaA
- Type 5 secretion system autotransporter AtaA
|
| Gene Name
| ATAA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Responsible for autoagglutination, and for adhesion to abiotic and biotic surfaces such as polystyrene (PS), type I collagen, polypropylene (PP), polyvinylchloride (PVC), glass and stainless steel (SS). Adhesion is much stronger than that mediated by Yersinia YadA in a comparative assay. Confers autoagglutination and binding to PS, type I collagen, PP, PVC, glass and SS upon expression in Acinetobacter baylyi strain ADP1 (PubMed:23155410). Involved in rapid, irreversible adherence to polyurethane (PubMed:17090933). Forms an unusual biofilm (PubMed:31972092). An extended, surface exposed fiber binds to quartz crystals, PS and glass. It can be removed by washing in distilled water (PubMed:27305955, PubMed:28720107). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| protein transport |
| cell adhesion |
| pathogenesis |
| Cellular Component |
| cell surface |
| cell outer membrane |
| integral to membrane |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 359306.795 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 3575-3585;3589-3599;3608-3614;3618-3629;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| K7ZP88 |
| UniProtKB/Swiss-Prot Entry Name
| ATAA_ACIS5 |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Ishikawa M, Nakatani H, Hori K: AtaA, a new member of the trimeric autotransporter adhesins from Acinetobacter sp. Tol 5 mediating high adhesiveness to various abiotic surfaces. PLoS One. 2012;7(11):e48830. doi: 10.1371/journal.pone.0048830. Epub 2012 Nov 14. [PubMed:23155410 ]
- Ishii S, Unno H, Miyata S, Hori K: Effect of cell appendages on the adhesion properties of a highly adhesive bacterium, Acinetobacter sp. Tol 5. Biosci Biotechnol Biochem. 2006 Nov;70(11):2635-40. doi: 10.1271/bbb.60236. Epub 2006 Nov 7. [PubMed:17090933 ]
- Ishikawa M, Shigemori K, Hori K: Application of the adhesive bacterionanofiber AtaA to a novel microbial immobilization method for the production of indigo as a model chemical. Biotechnol Bioeng. 2014 Jan;111(1):16-24. doi: 10.1002/bit.25012. Epub 2013 Aug 22. [PubMed:23893702 ]
- Ishikawa M, Yoshimoto S, Hayashi A, Kanie J, Hori K: Discovery of a novel periplasmic protein that forms a complex with a trimeric autotransporter adhesin and peptidoglycan. Mol Microbiol. 2016 Aug;101(3):394-410. doi: 10.1111/mmi.13398. Epub 2016 May 6. [PubMed:27074146 ]
- Yoshimoto S, Nakatani H, Iwasaki K, Hori K: An Acinetobacter trimeric autotransporter adhesin reaped from cells exhibits its nonspecific stickiness via a highly stable 3D structure. Sci Rep. 2016 Jun 16;6:28020. doi: 10.1038/srep28020. [PubMed:27305955 ]
- Yoshimoto S, Ohara Y, Nakatani H, Hori K: Reversible bacterial immobilization based on the salt-dependent adhesion of the bacterionanofiber protein AtaA. Microb Cell Fact. 2017 Jul 18;16(1):123. doi: 10.1186/s12934-017-0740-7. [PubMed:28720107 ]
- Aoki S, Yoshimoto S, Ishikawa M, Linke D, Lupas A, Hori K: Native display of a huge homotrimeric protein fiber on the cell surface after precise domain deletion. J Biosci Bioeng. 2020 Apr;129(4):412-417. doi: 10.1016/j.jbiosc.2019.09.022. Epub 2019 Oct 22. [PubMed:31653547 ]
- Koiwai K, Hartmann MD, Linke D, Lupas AN, Hori K: Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin. J Biol Chem. 2016 Feb 19;291(8):3705-24. doi: 10.1074/jbc.M115.701698. Epub 2015 Dec 23. [PubMed:26698633 ]
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