Hmdb loader
Identification
HMDB Protein ID HMDBP14022
Secondary Accession Numbers None
Name Zinc finger protein SNAI1
Synonyms
  1. Protein snail homolog 1
  2. Protein sna
Gene Name SNAI1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Pathways
  • Adherens junction
Reactions Not Available
GO Classification
Biological Process
positive regulation of cell migration
cell migration
palate development
heterochromatin organization
positive regulation of epithelial to mesenchymal transition
epithelial to mesenchymal transition
aortic valve morphogenesis
cartilage morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
negative regulation of cell differentiation involved in embryonic placenta development
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of vitamin D biosynthetic process
Notch signaling involved in heart development
regulation of bicellular tight junction assembly
trophoblast giant cell differentiation
osteoblast differentiation
regulation of transcription from RNA polymerase II promoter
left/right pattern formation
positive regulation of transcription, DNA-dependent
negative regulation of transcription from RNA polymerase II promoter
mesoderm formation
hair follicle morphogenesis
negative regulation of DNA damage response, signal transduction by p53 class mediator
Cellular Component
cytosol
cytoplasm
nucleus
centromeric heterochromatin
nucleoplasm
fibrillar center
intracellular membrane-bounded organelle
Molecular Function
metal ion binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II transcription regulatory region sequence-specific DNA binding
sequence-specific DNA binding transcription factor activity
kinase binding
E-box binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific double-stranded DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 264
Molecular Weight 29082.725
Theoretical pI 8.644
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95863
UniProtKB/Swiss-Prot Entry Name SNAI1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  12. Yamasaki H, Sekimoto T, Ohkubo T, Douchi T, Nagata Y, Ozawa M, Yoneda Y: Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway. Genes Cells. 2005 May;10(5):455-64. doi: 10.1111/j.1365-2443.2005.00850.x. [PubMed:15836774 ]
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  15. Lin Y, Wu Y, Li J, Dong C, Ye X, Chi YI, Evers BM, Zhou BP: The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J. 2010 Jun 2;29(11):1803-16. doi: 10.1038/emboj.2010.63. Epub 2010 Apr 13. [PubMed:20389281 ]
  16. Park SY, Kim HS, Kim NH, Ji S, Cha SY, Kang JG, Ota I, Shimada K, Konishi N, Nam HW, Hong SW, Yang WH, Roth J, Yook JI, Cho JW: Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition. EMBO J. 2010 Nov 17;29(22):3787-96. doi: 10.1038/emboj.2010.254. Epub 2010 Oct 19. [PubMed:20959806 ]
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  18. Lim SO, Kim H, Jung G: p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. FEBS Lett. 2010 Jun 3;584(11):2231-6. doi: 10.1016/j.febslet.2010.04.006. Epub 2010 Apr 10. [PubMed:20385133 ]
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