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Identification
HMDB Protein ID HMDBP14042
Secondary Accession Numbers None
Name Protein VAC14 homolog
Synonyms
  1. Tax1-binding protein 2
Gene Name VAC14
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Pathways
  • Human T-cell leukemia virus 1 infection
  • Viral carcinogenesis
Reactions Not Available
GO Classification
Biological Process
signal transduction
phosphatidylinositol biosynthetic process
positive regulation of kinase activity
viral reproduction
Cellular Component
cytosol
endoplasmic reticulum
early endosome membrane
extrinsic component of vacuolar membrane
PAS complex
late endosome membrane
endosome membrane
intracellular membrane-bounded organelle
Golgi membrane
Molecular Function
signaling receptor activity
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 782
Molecular Weight 87971.655
Theoretical pI 6.13
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q08AM6
UniProtKB/Swiss-Prot Entry Name VAC14_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
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  16. Lemaire JF, McPherson PS: Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif. FEBS Lett. 2006 Dec 22;580(30):6948-54. doi: 10.1016/j.febslet.2006.11.061. Epub 2006 Dec 4. [PubMed:17161399 ]
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