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Identification
HMDB Protein ID HMDBP14075
Secondary Accession Numbers None
Name V-type proton ATPase subunit G 1
Synonyms
  1. V-ATPase subunit G 1
  2. V-ATPase 13 kDa subunit 1
  3. Vacuolar proton pump subunit G 1
Gene Name ATP6V1G1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).
Pathways
  • Collecting duct acid secretion
  • Human papillomavirus infection
  • mTOR signaling pathway
  • Oxidative phosphorylation
  • Phagosome
  • Rheumatoid arthritis
  • Synaptic vesicle cycle
Reactions Not Available
GO Classification
Biological Process
cellular iron ion homeostasis
cellular response to increased oxygen levels
Cellular Component
cytosol
plasma membrane
vacuolar proton-transporting V-type ATPase complex
lysosomal membrane
Molecular Function
ATPase binding
ATPase activity
proton-transporting ATPase activity, rotational mechanism
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 118
Molecular Weight 13724.305
Theoretical pI 7.971
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9CR51
UniProtKB/Swiss-Prot Entry Name VATG1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  4. Sun-Wada GH, Yoshimizu T, Imai-Senga Y, Wada Y, Futai M: Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Gene. 2003 Jan 2;302(1-2):147-53. doi: 10.1016/s0378-1119(02)01099-5. [PubMed:12527205 ]
  5. Frische S, Chambrey R, Trepiccione F, Zamani R, Marcussen N, Alexander RT, Skjodt K, Svenningsen P, Dimke H: H(+)-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F429-F444. doi: 10.1152/ajprenal.00539.2017. Epub 2018 Jul 11. [PubMed:29993276 ]