Hmdb loader
Identification
HMDB Protein ID HMDBP14085
Secondary Accession Numbers None
Name Aminopeptidase N
Synonyms
  1. AP-N
  2. cAPN
  3. Alanyl aminopeptidase
  4. Aminopeptidase M
  5. Microsomal aminopeptidase
  6. AP-M
Gene Name ANPEP
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).(Microbial infection) Probable receptor for canine coronavirus (CCoV).
Pathways
  • Glutathione metabolism
  • Hematopoietic cell lineage
  • Renin-angiotensin system
Reactions Not Available
GO Classification
Biological Process
signal transduction
peptide catabolic process
angiogenesis
cell differentiation
proteolysis
regulation of blood pressure
Cellular Component
cytoplasm
plasma membrane
external side of plasma membrane
integral to membrane
Molecular Function
viral receptor activity
peptide binding
zinc ion binding
metalloaminopeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 975
Molecular Weight 110255.91
Theoretical pI 6.175
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 12-32;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P79143
UniProtKB/Swiss-Prot Entry Name AMPN_CANLF
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  2. Benbacer L, Kut E, Besnardeau L, Laude H, Delmas B: Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus. J Virol. 1997 Jan;71(1):734-7. doi: 10.1128/JVI.71.1.734-737.1997. [PubMed:8985407 ]