| Identification |
|---|
| HMDB Protein ID
| HMDBP14087 |
| Secondary Accession Numbers
| None |
| Name
| Aminopeptidase N |
| Synonyms
|
- AP-N
- fAPN
- Alanyl aminopeptidase
- Aminopeptidase M
- Microsomal aminopeptidase
- AP-M
|
| Gene Name
| ANPEP |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).(Microbial infection) In case of feline coronavirus (FCoV) infection, serves as a receptor for FCoV spike glycoprotein. It is as well a receptor for other serogroup I coronaviruses, like canine coronavirus (CCoV), porcine transmissible gastroenteritis virus (TGEV), and human coronavirus 229E (HCoV-229E). Also serves as a receptor for infectious bronchitis virus (IBV, Arkansas 99 serotype) in serogroup III. |
| Pathways
|
- Glutathione metabolism
- Hematopoietic cell lineage
- Renin-angiotensin system
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| signal transduction |
| peptide catabolic process |
| angiogenesis |
| cell differentiation |
| proteolysis |
| regulation of blood pressure |
| Cellular Component |
| cytoplasm |
| plasma membrane |
| integral to membrane |
| Molecular Function |
| viral receptor activity |
| peptide binding |
| zinc ion binding |
| metalloaminopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 967 |
| Molecular Weight
| 109423.62 |
| Theoretical pI
| 6.324 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P79171 |
| UniProtKB/Swiss-Prot Entry Name
| AMPN_FELCA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Hegyi A, Kolb AF: Characterization of determinants involved in the feline infectious peritonitis virus receptor function of feline aminopeptidase N. J Gen Virol. 1998 Jun;79 ( Pt 6):1387-91. [PubMed:9634079 ]
- Tresnan DB, Levis R, Holmes KV: Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I. J Virol. 1996 Dec;70(12):8669-74. doi: 10.1128/JVI.70.12.8669-8674.1996. [PubMed:8970993 ]
- Kolb AF, Hegyi A, Maile J, Heister A, Hagemann M, Siddell SG: Molecular analysis of the coronavirus-receptor function of aminopeptidase N. Adv Exp Med Biol. 1998;440:61-7. doi: 10.1007/978-1-4615-5331-1_8. [PubMed:9782265 ]
- Miguel B, Pharr GT, Wang C: The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review. Arch Virol. 2002 Nov;147(11):2047-56. doi: 10.1007/s00705-002-0888-1. [PubMed:12417943 ]
|
