| Identification |
|---|
| HMDB Protein ID
| HMDBP14120 |
| Secondary Accession Numbers
| None |
| Name
| Myotubularin-related protein 2 |
| Synonyms
|
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase
- Phosphatidylinositol-3-phosphate phosphatase
|
| Gene Name
| MTMR2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:12045210, PubMed:16399794). Has phosphatase activity towards pho sphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:12045210, PubMed:16399794). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:12045210, PubMed:16399794). Stabilizes SBF2/MTMR13 at the membranes (PubMed:23297362). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (PubMed:23297362). |
| Pathways
|
- Inositol phosphate metabolism
- Phosphatidylinositol signaling system
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| neuron development |
| dendritic spine maintenance |
| negative regulation of excitatory postsynaptic membrane potential |
| negative regulation of receptor catabolic process |
| negative regulation of receptor internalization |
| positive regulation of early endosome to late endosome transport |
| negative regulation of myelination |
| phosphatidylinositol dephosphorylation |
| phosphatidylinositol metabolic process |
| inositol phosphate dephosphorylation |
| myelin assembly |
| negative regulation of endocytosis |
| regulation of phosphatidylinositol dephosphorylation |
| dephosphorylation |
| Cellular Component |
| cytosol |
| cytoplasm |
| dendrite |
| perinuclear region of cytoplasm |
| synaptic membrane |
| vacuolar membrane |
| nucleus |
| early endosome membrane |
| synaptic vesicle |
| dendritic spine |
| axon |
| postsynaptic density |
| intracellular membrane-bounded organelle |
| Molecular Function |
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity |
| phosphatidylinositol-3-phosphatase activity |
| phosphatidylinositol phosphate phosphatase activity |
| identical protein binding |
| protein tyrosine phosphatase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 643 |
| Molecular Weight
| 73231.4 |
| Theoretical pI
| 7.256 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9Z2D1 |
| UniProtKB/Swiss-Prot Entry Name
| MTMR2_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL: Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. Hum Mol Genet. 1998 Oct;7(11):1703-12. [PubMed:9736772 ]
- Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
- Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [PubMed:19468303 ]
- Villen J, Beausoleil SA, Gerber SA, Gygi SP: Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1488-93. doi: 10.1073/pnas.0609836104. Epub 2007 Jan 22. [PubMed:17242355 ]
- Berger P, Bonneick S, Willi S, Wymann M, Suter U: Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1. Hum Mol Genet. 2002 Jun 15;11(13):1569-79. doi: 10.1093/hmg/11.13.1569. [PubMed:12045210 ]
- Berger P, Schaffitzel C, Berger I, Ban N, Suter U: Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12177-82. doi: 10.1073/pnas.2132732100. Epub 2003 Oct 6. [PubMed:14530412 ]
- Berger P, Berger I, Schaffitzel C, Tersar K, Volkmer B, Suter U: Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. Hum Mol Genet. 2006 Feb 15;15(4):569-79. doi: 10.1093/hmg/ddi473. Epub 2006 Jan 6. [PubMed:16399794 ]
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