Hmdb loader
Identification
HMDB Protein ID HMDBP14122
Secondary Accession Numbers None
Name Shootin-1
Synonyms
  1. Shootin1
Gene Name SHTN1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
positive regulation of axon extension
positive regulation of neuron migration
Ras protein signal transduction
neuron projection morphogenesis
actin filament bundle retrograde transport
Cdc42 protein signal transduction
cytoplasmic actin-based contraction involved in cell motility
endoplasmic reticulum polarization
netrin-activated signaling pathway
regulation of establishment of cell polarity
substrate-dependent cell migration, cell extension
axonogenesis
Cellular Component
growth cone
microtubule cytoskeleton
cytoplasm
filopodium
perinuclear region of cytoplasm
axonal growth cone
perikaryon
lamellipodium
cell leading edge
axon
microtubule
microtubule associated complex
Molecular Function
actin filament binding
cadherin binding
kinesin binding
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 631
Molecular Weight 71639.35
Theoretical pI 5.331
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A0MZ66
UniProtKB/Swiss-Prot Entry Name SHOT1_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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