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Identification
HMDB Protein ID HMDBP14135
Secondary Accession Numbers None
Name Fermitin family homolog 2
Synonyms
  1. Kindlin-2
  2. Mitogen-inducible gene 2 protein
  3. Pleckstrin homology domain-containing family C member 1
  4. MIG-2
  5. PH domain-containing family C member 1
Gene Name FERMT2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of cell shape
substrate adhesion-dependent cell spreading
positive regulation of cell migration
integrin activation
negative regulation of fat cell differentiation
integrin-mediated signaling pathway
cell adhesion
positive regulation of epithelial to mesenchymal transition
regulation of cell morphogenesis
limb development
Wnt receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein kinase B signaling cascade
focal adhesion assembly
positive regulation of protein localization to nucleus
positive regulation of osteoblast differentiation
positive regulation of GTPase activity
transforming growth factor beta receptor signaling pathway
negative regulation of vascular permeability
negative regulation of cell death
positive regulation of substrate adhesion-dependent cell spreading
adherens junction maintenance
cell junction assembly
positive regulation of stress fiber assembly
positive regulation of integrin activation
positive regulation of mesenchymal stem cell proliferation
positive regulation of myosin light chain kinase activity
positive regulation of focal adhesion assembly
positive regulation of wound healing, spreading of epidermal cells
protein localization to cell junction
protein localization to membrane
cell-matrix adhesion
Cellular Component
cytosol
cell surface
I band
cell cortex
focal adhesion
cytoplasm
plasma membrane
cell junction
nucleus
nucleoplasm
adherens junction
lamellipodium membrane
stress fiber
cell-substrate junction
extrinsic to internal side of plasma membrane
Molecular Function
protein kinase binding
actin binding
phosphatidylinositol-3,4,5-trisphosphate binding
integrin binding
actin filament binding
SMAD binding
type I transforming growth factor beta receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 680
Molecular Weight 77859.865
Theoretical pI 6.7
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96AC1
UniProtKB/Swiss-Prot Entry Name FERM2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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