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Showing Protein Unconventional myosin-X (HMDBP14136)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14136
Secondary Accession Numbers None
Name Unconventional myosin-X
Synonyms
  1. Unconventional myosin-10
Gene Name MYO10
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).
Pathways
  • Fc gamma R-mediated phagocytosis
  • Pathogenic Escherichia coli infection
Reactions Not Available
GO Classification
Biological Process
cytoskeleton-dependent intracellular transport
regulation of cell shape
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of filopodium assembly
Cellular Component
myosin complex
cytosol
cell cortex
nucleolus
ruffle
plasma membrane
lamellipodium
filopodium membrane
filopodium tip
Molecular Function
actin-dependent ATPase activity
plus-end directed microfilament motor activity
spectrin binding
phosphatidylinositol-3,4,5-trisphosphate binding
ATP binding
actin filament binding
calmodulin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 2058
Molecular Weight 237344.975
Theoretical pI 6.213
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9HD67
UniProtKB/Swiss-Prot Entry Name MYO10_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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