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Identification
HMDB Protein ID HMDBP14136
Secondary Accession Numbers None
Name Unconventional myosin-X
Synonyms
  1. Unconventional myosin-10
Gene Name MYO10
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).
Pathways
  • Fc gamma R-mediated phagocytosis
  • Pathogenic Escherichia coli infection
Reactions Not Available
GO Classification
Biological Process
cytoskeleton-dependent intracellular transport
regulation of cell shape
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of filopodium assembly
Cellular Component
myosin complex
cytosol
cell cortex
nucleolus
ruffle
plasma membrane
lamellipodium
filopodium membrane
filopodium tip
Molecular Function
actin-dependent ATPase activity
plus-end directed microfilament motor activity
spectrin binding
phosphatidylinositol-3,4,5-trisphosphate binding
ATP binding
actin filament binding
calmodulin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 2058
Molecular Weight 237344.975
Theoretical pI 6.213
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9HD67
UniProtKB/Swiss-Prot Entry Name MYO10_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  2. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
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  4. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1998 Oct 30;5(5):277-86. [PubMed:9872452 ]
  5. Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54. doi: 10.1073/pnas.1210303109. Epub 2012 Jul 18. [PubMed:22814378 ]
  6. Berg JS, Derfler BH, Pennisi CM, Corey DP, Cheney RE: Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. J Cell Sci. 2000 Oct;113 Pt 19:3439-51. [PubMed:10984435 ]
  7. Rogers MS, Strehler EE: The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X. J Biol Chem. 2001 Apr 13;276(15):12182-9. doi: 10.1074/jbc.M010056200. Epub 2001 Jan 22. [PubMed:11278607 ]
  8. Rojas K, Serrano de la Pena L, Gallardo T, Simmons A, Nyce K, McGrath R, Considine E, Vasko AJ, Peterson E, Grady D, Cox R, Andrew LJ, Lovett M, Overhauser J, Williams CJ: Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome 5p15.1. Genomics. 1999 Dec 1;62(2):177-83. doi: 10.1006/geno.1999.5997. [PubMed:10610710 ]
  9. Sousa AD, Berg JS, Robertson BW, Meeker RB, Cheney RE: Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neurons. J Cell Sci. 2006 Jan 1;119(Pt 1):184-94. doi: 10.1242/jcs.02726. [PubMed:16371656 ]
  10. Bohil AB, Robertson BW, Cheney RE: Myosin-X is a molecular motor that functions in filopodia formation. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12411-6. doi: 10.1073/pnas.0602443103. Epub 2006 Aug 7. [PubMed:16894163 ]
  11. Bennett RD, Caride AJ, Mauer AS, Strehler EE: Interaction with the IQ3 motif of myosin-10 is required for calmodulin-like protein-dependent filopodial extension. FEBS Lett. 2008 Jul 9;582(16):2377-81. doi: 10.1016/j.febslet.2008.05.051. Epub 2008 Jun 18. [PubMed:18570893 ]
  12. Gorbea C, Pratt G, Ustrell V, Bell R, Sahasrabudhe S, Hughes RE, Rechsteiner M: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J Biol Chem. 2010 Oct 8;285(41):31616-33. doi: 10.1074/jbc.M110.154120. Epub 2010 Aug 3. [PubMed:20682791 ]
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