Hmdb loader
Identification
HMDB Protein ID HMDBP14212
Secondary Accession Numbers None
Name Alpha-2,8-sialyltransferase 8B
Synonyms
  1. Sialyltransferase 8B
  2. Sialyltransferase St8Sia II
  3. Sialyltransferase X
  4. SIAT8-B
  5. ST8SiaII
  6. STX
Gene Name ST8SIA2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.
Pathways
  • protein glycosylation
Reactions Not Available
GO Classification
Biological Process
ganglioside biosynthetic process
N-glycan processing
protein glycosylation
cellular protein modification process
oligosaccharide metabolic process
nervous system development
carbohydrate metabolic process
Cellular Component
early endosome
recycling endosome
integral to membrane
Golgi membrane
Molecular Function
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
sialic acid binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 375
Molecular Weight 42429.55
Theoretical pI 9.437
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 7-23;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q92186
UniProtKB/Swiss-Prot Entry Name SIA8B_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Kitagawa H, Paulson JC: Differential expression of five sialyltransferase genes in human tissues. J Biol Chem. 1994 Jul 8;269(27):17872-8. [PubMed:8027041 ]
  3. Scheidegger EP, Sternberg LR, Roth J, Lowe JB: A human STX cDNA confers polysialic acid expression in mammalian cells. J Biol Chem. 1995 Sep 29;270(39):22685-8. doi: 10.1074/jbc.270.39.22685. [PubMed:7559389 ]
  4. Angata K, Nakayama J, Fredette B, Chong K, Ranscht B, Fukuda M: Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. J Biol Chem. 1997 Mar 14;272(11):7182-90. doi: 10.1074/jbc.272.11.7182. [PubMed:9054414 ]