| Identification |
|---|
| HMDB Protein ID
| HMDBP14235 |
| Secondary Accession Numbers
| None |
| Name
| Outer capsid protein sigma-1 |
| Synonyms
|
- Sigma1
- Cell attachment protein
- Hemagglutinin
|
| Gene Name
| S1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral entry into host cell |
| virion attachment to host cell |
| cell adhesion |
| Cellular Component |
| viral outer capsid |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 49094.71 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P03528 |
| UniProtKB/Swiss-Prot Entry Name
| SIGM1_REOVD |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Cashdollar LW, Chmelo RA, Wiener JR, Joklik WK: Sequences of the S1 genes of the three serotypes of reovirus. Proc Natl Acad Sci U S A. 1985 Jan;82(1):24-8. doi: 10.1073/pnas.82.1.24. [PubMed:3855545 ]
- Duncan R, Horne D, Cashdollar LW, Joklik WK, Lee PW: Identification of conserved domains in the cell attachment proteins of the three serotypes of reovirus. Virology. 1990 Feb;174(2):399-409. doi: 10.1016/0042-6822(90)90093-7. [PubMed:2305549 ]
- Nagata L, Masri SA, Mah DC, Lee PW: Molecular cloning and sequencing of the reovirus (serotype 3) S1 gene which encodes the viral cell attachment protein sigma 1. Nucleic Acids Res. 1984 Nov 26;12(22):8699-710. doi: 10.1093/nar/12.22.8699. [PubMed:6095208 ]
- Bassel-Duby R, Jayasuriya A, Chatterjee D, Sonenberg N, Maizel JV Jr, Fields BN: Sequence of reovirus haemagglutinin predicts a coiled-coil structure. Nature. 1985 May 30-Jun 5;315(6018):421-3. doi: 10.1038/315421a0. [PubMed:4000269 ]
- Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS: A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007 Apr 19;1(2):147-57. doi: 10.1016/j.chom.2007.03.003. [PubMed:18005692 ]
- Chappell JD, Prota AE, Dermody TS, Stehle T: Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J. 2002 Jan 15;21(1-2):1-11. doi: 10.1093/emboj/21.1.1. [PubMed:11782420 ]
- Schelling P, Guglielmi KM, Kirchner E, Paetzold B, Dermody TS, Stehle T: The reovirus sigma1 aspartic acid sandwich: a trimerization motif poised for conformational change. J Biol Chem. 2007 Apr 13;282(15):11582-9. doi: 10.1074/jbc.M610805200. Epub 2007 Feb 15. [PubMed:17303562 ]
|
