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Identification
HMDB Protein ID HMDBP14278
Secondary Accession Numbers None
Name Sialic acid-binding Ig-like lectin 9
Synonyms
  1. Siglec-9
  2. CDw329
  3. Protein FOAP-9
Gene Name SIGLEC9
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Pathways
  • Neutrophil extracellular trap formation
Reactions Not Available
GO Classification
Biological Process
neutrophil degranulation
cell adhesion
cell surface receptor signaling pathway
regulation of immune response
Cellular Component
plasma membrane
secretory granule membrane
integral to plasma membrane
Molecular Function
carbohydrate binding
sialic acid binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 463
Molecular Weight 50081.17
Theoretical pI 7.257
Pfam Domain Function
Signals
  • 1-17;
Transmembrane Regions
  • 349-369;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Y336
UniProtKB/Swiss-Prot Entry Name SIGL9_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  6. Zhang JQ, Nicoll G, Jones C, Crocker PR: Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. J Biol Chem. 2000 Jul 21;275(29):22121-6. [PubMed:10801862 ]
  7. Angata T, Varki A: Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. J Biol Chem. 2000 Jul 21;275(29):22127-35. [PubMed:10801860 ]