| Identification |
|---|
| HMDB Protein ID
| HMDBP14318 |
| Secondary Accession Numbers
| None |
| Name
| Outer capsid protein sigma-1 |
| Synonyms
|
- Sigma1
- Cell attachment protein
- Hemagglutinin
|
| Gene Name
| S1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral entry into host cell |
| virion attachment to host cell |
| cell adhesion |
| Cellular Component |
| viral outer capsid |
| viral capsid |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 51403.275 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P04506 |
| UniProtKB/Swiss-Prot Entry Name
| SIGM1_REOVL |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Cashdollar LW, Chmelo RA, Wiener JR, Joklik WK: Sequences of the S1 genes of the three serotypes of reovirus. Proc Natl Acad Sci U S A. 1985 Jan;82(1):24-8. doi: 10.1073/pnas.82.1.24. [PubMed:3855545 ]
- Duncan R, Horne D, Cashdollar LW, Joklik WK, Lee PW: Identification of conserved domains in the cell attachment proteins of the three serotypes of reovirus. Virology. 1990 Feb;174(2):399-409. doi: 10.1016/0042-6822(90)90093-7. [PubMed:2305549 ]
- Nibert ML, Dermody TS, Fields BN: Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1. J Virol. 1990 Jun;64(6):2976-89. doi: 10.1128/JVI.64.6.2976-2989.1990. [PubMed:2335823 ]
- Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS: A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007 Apr 19;1(2):147-57. doi: 10.1016/j.chom.2007.03.003. [PubMed:18005692 ]
- Munemitsu SM, Atwater JA, Samuel CE: Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning and nucleotide sequence of the reovirus serotype 1 Lang strain bicistronic s1 mRNA which encodes the minor capsid polypeptide sigma 1a and the nonstructural polypeptide sigma 1bNS. Biochem Biophys Res Commun. 1986 Oct 30;140(2):508-14. doi: 10.1016/0006-291x(86)90761-8. [PubMed:2430568 ]
- Li JK, Keene JD, Scheible PP, Joklik WK: Nature of the 3'-terminal sequences of the plus and minus strands of the S1 gene of reovirus serotypes 1, 2 and 3. Virology. 1980 Aug;105(1):41-51. doi: 10.1016/0042-6822(80)90154-3. [PubMed:6158163 ]
|
