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HMDB Protein ID HMDBP14319
Secondary Accession Numbers None
Name Sialic acid-binding Ig-like lectin 14
  1. Siglec-14
Gene Name SIGLEC14
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
neutrophil degranulation
cell adhesion
innate immune response
Cellular Component
plasma membrane
ficolin-1-rich granule membrane
tertiary granule membrane
integral to membrane
Molecular Function
carbohydrate binding
sialic acid binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 396
Molecular Weight 43969.695
Theoretical pI 7.956
Pfam Domain Function
  • 1-16;
Transmembrane Regions
  • 359-381;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q08ET2
UniProtKB/Swiss-Prot Entry Name SIG14_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
General References
  1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
  2. Angata T, Hayakawa T, Yamanaka M, Varki A, Nakamura M: Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 2006 Oct;20(12):1964-73. doi: 10.1096/fj.06-5800com. [PubMed:17012248 ]