Hmdb loader
Identification
HMDB Protein ID HMDBP14329
Secondary Accession Numbers None
Name Hemagglutinin-neuraminidase
Synonyms
  1. HN protein
Gene Name HN
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
viral entry into host cell
virion attachment to host cell
regulation of immune response
Cellular Component
virion membrane
host cell plasma membrane
viral envelope
integral to membrane
Molecular Function
host cell surface receptor binding
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 63409.37
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 38-58;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P04853
UniProtKB/Swiss-Prot Entry Name HN_SENDZ
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Miura N, Nakatani Y, Ishiura M, Uchida T, Okada Y: Molecular cloning of a full-length cDNA encoding the hemagglutinin-neuraminidase glycoprotein of Sendai virus. FEBS Lett. 1985 Aug 19;188(1):112-6. doi: 10.1016/0014-5793(85)80885-1. [PubMed:2991016 ]
  2. Shioda T, Iwasaki K, Shibuta H: Determination of the complete nucleotide sequence of the Sendai virus genome RNA and the predicted amino acid sequences of the F, HN and L proteins. Nucleic Acids Res. 1986 Feb 25;14(4):1545-63. doi: 10.1093/nar/14.4.1545. [PubMed:3005975 ]
  3. Middleton Y, Tashiro M, Thai T, Oh J, Seymour J, Pritzer E, Klenk HD, Rott R, Seto JT: Nucleotide sequence analyses of the genes encoding the HN, M, NP, P, and L proteins of two host range mutants of Sendai virus. Virology. 1990 Jun;176(2):656-7. doi: 10.1016/0042-6822(90)90040-x. [PubMed:2161155 ]
  4. Tashiro M, James I, Karri S, Wahn K, Tobita K, Klenk HD, Rott R, Seto JT: Pneumotropic revertants derived from a pantropic mutant, F1-R, of Sendai virus. Virology. 1991 Sep;184(1):227-34. doi: 10.1016/0042-6822(91)90839-4. [PubMed:1651590 ]
  5. Markwell MA, Paulson JC: Sendai virus utilizes specific sialyloligosaccharides as host cell receptor determinants. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5693-7. doi: 10.1073/pnas.77.10.5693. [PubMed:6255459 ]
  6. Bousse T, Takimoto T, Gorman WL, Takahashi T, Portner A: Regions on the hemagglutinin-neuraminidase proteins of human parainfluenza virus type-1 and Sendai virus important for membrane fusion. Virology. 1994 Nov 1;204(2):506-14. doi: 10.1006/viro.1994.1564. [PubMed:7941317 ]
  7. Tanabayashi K, Compans RW: Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion. J Virol. 1996 Sep;70(9):6112-8. doi: 10.1128/JVI.70.9.6112-6118.1996. [PubMed:8709235 ]
  8. Takimoto T, Bousse T, Coronel EC, Scroggs RA, Portner A: Cytoplasmic domain of Sendai virus HN protein contains a specific sequence required for its incorporation into virions. J Virol. 1998 Dec;72(12):9747-54. doi: 10.1128/JVI.72.12.9747-9754.1998. [PubMed:9811709 ]
  9. Ali A, Nayak DP: Assembly of Sendai virus: M protein interacts with F and HN proteins and with the cytoplasmic tail and transmembrane domain of F protein. Virology. 2000 Oct 25;276(2):289-303. doi: 10.1006/viro.2000.0556. [PubMed:11040121 ]