| Identification |
|---|
| HMDB Protein ID
| HMDBP14338 |
| Secondary Accession Numbers
| None |
| Name
| B-cell receptor CD22 |
| Synonyms
|
- Sialic acid-binding Ig-like lectin 2
- Siglec-2
|
| Gene Name
| CD22 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| cell adhesion |
| regulation of B cell proliferation |
| negative regulation of B cell receptor signaling pathway |
| B cell activation |
| Cellular Component |
| early endosome |
| recycling endosome |
| external side of plasma membrane |
| integral to plasma membrane |
| Molecular Function |
| carbohydrate binding |
| CD4 receptor binding |
| sialic acid binding |
| protein phosphatase binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 37728.705 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9N1E6 |
| UniProtKB/Swiss-Prot Entry Name
| CD22_PANTR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Brinkman-Van der Linden EC, Sjoberg ER, Juneja LR, Crocker PR, Varki N, Varki A: Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs. J Biol Chem. 2000 Mar 24;275(12):8633-40. doi: 10.1074/jbc.275.12.8633. [PubMed:10722703 ]
|
