Hmdb loader
Identification
HMDB Protein ID HMDBP14340
Secondary Accession Numbers None
Name Asialoglycoprotein receptor 2
Synonyms
  1. ASGP-R 2
  2. ASGPR 2
  3. Hepatic lectin R2/3
  4. HL-2
  5. rHL-2
Gene Name ASGR2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Pathways
  • Thyroid hormone synthesis
Reactions Not Available
GO Classification
Biological Process
regulation of protein stability
bone mineralization
lipid homeostasis
glycoprotein metabolic process
endocytosis
Cellular Component
perinuclear region of cytoplasm
endoplasmic reticulum quality control compartment
integral to membrane
Molecular Function
carbohydrate binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 301
Molecular Weight 35026.93
Theoretical pI 5.243
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 59-79;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P08290
UniProtKB/Swiss-Prot Entry Name ASGR2_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Zeng FY, Weigel PH: Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits. J Biol Chem. 1996 Dec 13;271(50):32454-60. [PubMed:8943311 ]
  3. Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871. [PubMed:22673903 ]
  4. McPhaul M, Berg P: Identification and characterization of cDNA clones encoding two homologous proteins that are part of the asialoglycoprotein receptor. Mol Cell Biol. 1987 May;7(5):1841-7. doi: 10.1128/mcb.7.5.1841-1847.1987. [PubMed:3600647 ]
  5. Halberg DF, Wager RE, Farrell DC, Hildreth J 4th, Quesenberry MS, Loeb JA, Holland EC, Drickamer K: Major and minor forms of the rat liver asialoglycoprotein receptor are independent galactose-binding proteins. Primary structure and glycosylation heterogeneity of minor receptor forms. J Biol Chem. 1987 Jul 15;262(20):9828-38. [PubMed:3597443 ]
  6. Sanford JP, Elliott RW, Doyle D: Asialoglycoprotein receptor genes are linked on chromosome 11 in the mouse. DNA. 1988 Dec;7(10):721-8. doi: 10.1089/dna.1988.7.721. [PubMed:3234178 ]