Identification |
HMDB Protein ID
| HMDBP14344 |
Secondary Accession Numbers
| None |
Name
| Hemagglutinin-neuraminidase |
Synonyms
|
Not Available
|
Gene Name
| HN |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
viral entry into host cell |
virion attachment to host cell |
Cellular Component |
virion membrane |
host cell plasma membrane |
viral envelope |
integral to membrane |
Molecular Function |
host cell surface receptor binding |
exo-alpha-(2->3)-sialidase activity |
exo-alpha-(2->6)-sialidase activity |
exo-alpha-(2->8)-sialidase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 63261.85 |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P25466 |
UniProtKB/Swiss-Prot Entry Name
| HN_PI2HT |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Kawano M, Bando H, Yuasa T, Kondo K, Tsurudome M, Komada H, Nishio M, Ito Y: Sequence determination of the hemagglutinin-neuraminidase (HN) gene of human parainfluenza type 2 virus and the construction of a phylogenetic tree for HN proteins of all the paramyxoviruses that are infectious to humans. Virology. 1990 Jan;174(1):308-13. doi: 10.1016/0042-6822(90)90081-2. [PubMed:2152995 ]
|