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Showing Protein Hemagglutinin-neuraminidase (HMDBP14348)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14348
Secondary Accession Numbers None
Name Hemagglutinin-neuraminidase
Synonyms Not Available
Gene Name HN
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
viral entry into host cell
virion attachment to host cell
Cellular Component
virion membrane
host cell plasma membrane
viral envelope
integral to membrane
Molecular Function
host cell surface receptor binding
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 64246.735
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 32-52;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P08492
UniProtKB/Swiss-Prot Entry Name HN_PI3H4
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Storey DG, Cote MJ, Dimock K, Kang CY: Nucleotide sequence of the coding and flanking regions of the human parainfluenza virus 3 hemagglutinin-neuraminidase gene: comparison with other paramyxoviruses. Intervirology. 1987;27(2):69-80. [PubMed:2822598 ]
  2. Elango N, Coligan JE, Jambou RC, Venkatesan S: Human parainfluenza type 3 virus hemagglutinin-neuraminidase glycoprotein: nucleotide sequence of mRNA and limited amino acid sequence of the purified protein. J Virol. 1986 Feb;57(2):481-9. doi: 10.1128/JVI.57.2.481-489.1986. [PubMed:3003381 ]
  3. Galinski MS, Mink MA, Pons MW: Molecular cloning and sequence analysis of the human parainfluenza 3 virus genes encoding the surface glycoproteins, F and HN. Virus Res. 1987 Sep;8(3):205-15. doi: 10.1016/0168-1702(87)90016-5. [PubMed:2825443 ]
  4. Huberman K, Peluso RW, Moscona A: Hemagglutinin-neuraminidase of human parainfluenza 3: role of the neuraminidase in the viral life cycle. Virology. 1995 Dec 1;214(1):294-300. doi: 10.1006/viro.1995.9925. [PubMed:8525632 ]