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Showing Protein B-cell receptor CD22 (HMDBP14349)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14349
Secondary Accession Numbers None
Name B-cell receptor CD22
Synonyms
  1. Sialic acid-binding Ig-like lectin 2
  2. Siglec-2
Gene Name CD22
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
cell adhesion
regulation of B cell proliferation
negative regulation of B cell receptor signaling pathway
B cell activation
Cellular Component
early endosome
recycling endosome
external side of plasma membrane
integral to plasma membrane
Molecular Function
carbohydrate binding
CD4 receptor binding
sialic acid binding
protein phosphatase binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 37788.705
Theoretical pI Not Available
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9N1E4
UniProtKB/Swiss-Prot Entry Name CD22_GORGO
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Brinkman-Van der Linden EC, Sjoberg ER, Juneja LR, Crocker PR, Varki N, Varki A: Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs. J Biol Chem. 2000 Mar 24;275(12):8633-40. doi: 10.1074/jbc.275.12.8633. [PubMed:10722703 ]