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Showing Protein Asialoglycoprotein receptor 1 (HMDBP14350)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14350
Secondary Accession Numbers None
Name Asialoglycoprotein receptor 1
Synonyms
  1. ASGP-R 1
  2. ASGPR 1
  3. Hepatic lectin 1
  4. HL-1
  5. rHL-1
Gene Name ASGR1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Pathways
  • Thyroid hormone synthesis
Reactions Not Available
GO Classification
Biological Process
cellular response to extracellular stimulus
Cellular Component
integral to membrane
Molecular Function
metal ion binding
carbohydrate binding
asialoglycoprotein receptor activity
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 284
Molecular Weight 32848.725
Theoretical pI 6.179
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 40-60;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P02706
UniProtKB/Swiss-Prot Entry Name ASGR1_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Zeng FY, Weigel PH: Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits. J Biol Chem. 1996 Dec 13;271(50):32454-60. [PubMed:8943311 ]
  3. Holland EC, Leung JO, Drickamer K: Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7338-42. doi: 10.1073/pnas.81.23.7338. [PubMed:6095287 ]
  4. Leung JO, Holland EC, Drickamer K: Characterization of the gene encoding the major rat liver asialoglycoprotein receptor. J Biol Chem. 1985 Oct 15;260(23):12523-7. [PubMed:2995379 ]
  5. Watts C: Isolation and expression of cDNA clones for a rat liver asialoglycoprotein receptor. Biosci Rep. 1986 Jun;6(6):527-34. doi: 10.1007/BF01114949. [PubMed:2945599 ]