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Showing Protein Hemagglutinin-neuraminidase (HMDBP14355)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14355
Secondary Accession Numbers None
Name Hemagglutinin-neuraminidase
Synonyms Not Available
Gene Name HN
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
viral entry into host cell
virion attachment to host cell
viral budding from plasma membrane
Cellular Component
virion membrane
host cell plasma membrane
viral envelope
integral to membrane
Molecular Function
host cell surface receptor binding
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 62204.3
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 20-40;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P04850
UniProtKB/Swiss-Prot Entry Name HN_PIV5
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Baty DU, Southern JA, Randall RE: Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5. J Gen Virol. 1991 Dec;72 ( Pt 12):3103-7. doi: 10.1099/0022-1317-72-12-3103. [PubMed:1765772 ]
  2. Hiebert SW, Paterson RG, Lamb RA: Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor. J Virol. 1985 Apr;54(1):1-6. doi: 10.1128/JVI.54.1.1-6.1985. [PubMed:3973974 ]
  3. Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS: Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose. Structure. 2005 May;13(5):803-15. doi: 10.1016/j.str.2005.02.019. [PubMed:15893670 ]