Identification |
HMDB Protein ID
| HMDBP14393 |
Secondary Accession Numbers
| None |
Name
| Neuraminidase |
Synonyms
|
Not Available
|
Gene Name
| NA |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication. |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
virion attachment to host cell |
viral entry into host cell via membrane fusion with the plasma membrane |
viral budding from plasma membrane |
induction by virus of host immune response |
intracellular transport of viral protein in host cell |
uncoating of virus |
viral genome packaging |
viral release from host cell |
virion assembly |
carbohydrate metabolic process |
receptor-mediated endocytosis of virus by host cell |
Cellular Component |
extracellular region |
virion membrane |
host cell plasma membrane |
integral to membrane |
Molecular Function |
metal ion binding |
exo-alpha-(2->3)-sialidase activity |
exo-alpha-(2->6)-sialidase activity |
exo-alpha-(2->8)-sialidase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 454 |
Molecular Weight
| 50120.235 |
Theoretical pI
| 7.136 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P03468 |
UniProtKB/Swiss-Prot Entry Name
| NRAM_I34A1 |
PDB IDs
|
|
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Schickli JH, Flandorfer A, Nakaya T, Martinez-Sobrido L, Garcia-Sastre A, Palese P: Plasmid-only rescue of influenza A virus vaccine candidates. Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1965-73. [PubMed:11779399 ]
- de Wit E, Spronken MI, Bestebroer TM, Rimmelzwaan GF, Osterhaus AD, Fouchier RA: Efficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragments. Virus Res. 2004 Jul;103(1-2):155-61. [PubMed:15163504 ]
- Moscona A: Neuraminidase inhibitors for influenza. N Engl J Med. 2005 Sep 29;353(13):1363-73. doi: 10.1056/NEJMra050740. [PubMed:16192481 ]
- Nayak DP, Hui EK, Barman S: Assembly and budding of influenza virus. Virus Res. 2004 Dec;106(2):147-65. doi: 10.1016/j.virusres.2004.08.012. [PubMed:15567494 ]
- Suzuki Y: Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol Pharm Bull. 2005 Mar;28(3):399-408. doi: 10.1248/bpb.28.399. [PubMed:15744059 ]
- Blok J, Air GM: Sequence variation at the 3' end of the neuraminidase gene from 39 influenza type A viruses. Virology. 1982 Sep;121(2):211-29. doi: 10.1016/0042-6822(82)90162-3. [PubMed:6927853 ]
- Fields S, Winter G, Brownlee GG: Structure of the neuraminidase gene in human influenza virus A/PR/8/34. Nature. 1981 Mar 19;290(5803):213-7. doi: 10.1038/290213a0. [PubMed:7010182 ]
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