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Showing Protein Baculoviral IAP repeat-containing protein 7 (HMDBP14440)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14440
Secondary Accession Numbers None
Name Baculoviral IAP repeat-containing protein 7
Synonyms
  1. Kidney inhibitor of apoptosis protein
  2. Livin
  3. Melanoma inhibitor of apoptosis protein
  4. RING finger protein 50
  5. RING-type E3 ubiquitin transferase BIRC7
  6. KIAP
  7. ML-IAP
Gene Name BIRC7
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
Pathways
  • Apoptosis - multiple species
  • Small cell lung cancer
  • Toxoplasmosis
  • Ubiquitin mediated proteolysis
Reactions Not Available
GO Classification
Biological Process
regulation of cell proliferation
negative regulation of apoptotic process
positive regulation of protein ubiquitination
lens development in camera-type eye
activation of JUN kinase activity
regulation of natural killer cell apoptotic process
regulation of cell cycle
protein ubiquitination
Cellular Component
cytosol
centrosome
cytoplasm
Golgi apparatus
nucleus
nucleoplasm
Molecular Function
cysteine-type endopeptidase inhibitor activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
ubiquitin-protein ligase activity
metal ion binding
ubiquitin protein ligase activity
enzyme binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 298
Molecular Weight 32797.655
Theoretical pI 5.649
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96CA5
UniProtKB/Swiss-Prot Entry Name BIRC7_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
  4. Lin JH, Deng G, Huang Q, Morser J: KIAP, a novel member of the inhibitor of apoptosis protein family. Biochem Biophys Res Commun. 2000 Dec 29;279(3):820-31. doi: 10.1006/bbrc.2000.4027. [PubMed:11162435 ]
  5. Ashhab Y, Alian A, Polliack A, Panet A, Ben Yehuda D: Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. FEBS Lett. 2001 Apr 20;495(1-2):56-60. doi: 10.1016/s0014-5793(01)02366-3. [PubMed:11322947 ]
  6. Kasof GM, Gomes BC: Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem. 2001 Feb 2;276(5):3238-46. doi: 10.1074/jbc.M003670200. Epub 2000 Oct 9. [PubMed:11024045 ]
  7. Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM: SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP). J Biol Chem. 2002 Apr 5;277(14):12275-9. doi: 10.1074/jbc.M112045200. Epub 2002 Jan 18. [PubMed:11801603 ]
  8. Sanna MG, da Silva Correia J, Ducrey O, Lee J, Nomoto K, Schrantz N, Deveraux QL, Ulevitch RJ: IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. Mol Cell Biol. 2002 Mar;22(6):1754-66. doi: 10.1128/MCB.22.6.1754-1766.2002. [PubMed:11865055 ]
  9. Ma L, Huang Y, Song Z, Feng S, Tian X, Du W, Qiu X, Heese K, Wu M: Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. Cell Death Differ. 2006 Dec;13(12):2079-88. doi: 10.1038/sj.cdd.4401959. Epub 2006 May 26. [PubMed:16729033 ]
  10. Nachmias B, Mizrahi S, Elmalech M, Lazar I, Ashhab Y, Gazit R, Markel G, Ben-Yehuda D, Mandelboim O: Manipulation of NK cytotoxicity by the IAP family member Livin. Eur J Immunol. 2007 Dec;37(12):3467-76. doi: 10.1002/eji.200636600. [PubMed:18034418 ]
  11. Wang L, Zhang Q, Liu B, Han M, Shan B: Challenge and promise: roles for Livin in progression and therapy of cancer. Mol Cancer Ther. 2008 Dec;7(12):3661-9. doi: 10.1158/1535-7163.MCT-08-0480. [PubMed:19074843 ]
  12. Yan B: Research progress on Livin protein: an inhibitor of apoptosis. Mol Cell Biochem. 2011 Nov;357(1-2):39-45. doi: 10.1007/s11010-011-0873-7. Epub 2011 May 27. [PubMed:21617971 ]
  13. Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ: Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP). Biochemistry. 2003 Jul 15;42(27):8223-31. doi: 10.1021/bi034227t. [PubMed:12846571 ]
  14. Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ: Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 1;385(Pt 1):11-20. doi: 10.1042/BJ20041108. [PubMed:15485396 ]