| Identification |
|---|
| HMDB Protein ID
| HMDBP14441 |
| Secondary Accession Numbers
| None |
| Name
| Bifunctional alpha-galactosidase/sucrose kinase AgaSK |
| Synonyms
|
Not Available
|
| Gene Name
| AGASK |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Bifunctional enzyme with alpha-galactosidase and sucrose kinase activities. Produces sucrose-6-phosphate directly from raffinose. Binds ATP. Phosphorylates sucrose specifically on the C6 position of glucose in the presence of ATP. Hydrolyzes melibiose, raffinose, stachyose and synthetic substrate p-nitrophenyl-alpha-D-galactopyranoside with high activity. Low activity against locust bean gum, guar gum and synthetic substrates xylose alpha-D-4-nitrophenol, glucose alpha-D-4-nitrophenol and o-nitrophenyl-alpha-D-galactopyranoside. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| melibiose catabolic process |
| raffinose catabolic process |
| stachyose metabolic process |
| protein homotetramerization |
| Molecular Function |
| nucleotidyltransferase activity |
| magnesium ion binding |
| ATP binding |
| alpha-galactosidase activity |
| raffinose alpha-galactosidase activity |
| carbohydrate kinase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 105513.57 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| G4T4R7 |
| UniProtKB/Swiss-Prot Entry Name
| AGASK_RUMGN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Bruel L, Sulzenbacher G, Cervera Tison M, Pujol A, Nicoletti C, Perrier J, Galinier A, Ropartz D, Fons M, Pompeo F, Giardina T: alpha-Galactosidase/sucrose kinase (AgaSK), a novel bifunctional enzyme from the human microbiome coupling galactosidase and kinase activities. J Biol Chem. 2011 Nov 25;286(47):40814-23. doi: 10.1074/jbc.M111.286039. Epub 2011 Sep 19. [PubMed:21931163 ]
|
