Hmdb loader
Identification
HMDB Protein ID HMDBP14442
Secondary Accession Numbers None
Name Orexin receptor type 1
Synonyms
  1. Ox-1-R
  2. Ox1-R
  3. Ox1R
  4. Hypocretin receptor type 1
Gene Name HCRTR1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
Pathways
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
positive regulation of ERK1 and ERK2 cascade
feeding behavior
cytosolic calcium ion homeostasis
synaptic transmission
Cellular Component
plasma membrane
synapse
integral to plasma membrane
Molecular Function
orexin receptor activity
peptide hormone binding
G protein-coupled receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 425
Molecular Weight 47535.33
Theoretical pI 9.107
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 47-67;83-105;120-140;161-182;214-235;299-321;337-360;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O43613
UniProtKB/Swiss-Prot Entry Name OX1R_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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