| Identification |
|---|
| HMDB Protein ID
| HMDBP14444 |
| Secondary Accession Numbers
| None |
| Name
| Thrombin-like enzyme BpSP-1 |
| Synonyms
|
- SVTLE BpSP-1
- Fibrinogen-clotting enzyme
- Snake venom serine protease
- Thrombin-like enzyme BpSP-I
- SVSP
- SVTLE BpSP-I
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Thrombin-like enzyme that has high clotting activity upon bovine and human plasma. Has also fibrinogenoltic activity by rapidly hydrolyzing Aalpha chain of fibrinogen (FGA), and partially consumes Bbeta chain (FGB). Has high catalytic activity upon substrates such as TAME, and specific substrates for thrombin S-2238 and S-2288. Also hydrolyzes specific substrates for kallikrein (S-2266 and S-2302), however, no release of kinin upon plasma has been determined. When administered intraperitoneally in mice, causes defibrinogenation, making the plasma incoagulable. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type peptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 1657.8 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DJF1 |
| UniProtKB/Swiss-Prot Entry Name
| VSP1_BOTPA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Costa FL, Rodrigues RS, Izidoro LF, Menaldo DL, Hamaguchi A, Homsi-Brandeburgo MI, Fuly AL, Soares SG, Selistre-de-Araujo HS, Barraviera B, Soares AM, Rodrigues VM: Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom. Toxicon. 2009 Nov;54(6):725-35. doi: 10.1016/j.toxicon.2009.05.040. Epub 2009 Jun 17. [PubMed:19539638 ]
|
