Hmdb loader
Identification
HMDB Protein ID HMDBP14453
Secondary Accession Numbers None
Name Cyclase atC
Synonyms
  1. Terreic acid biosynthesis cluster protein C
Gene Name ATC
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Cyclase; part of the gene cluster that mediates the biosynthesis of terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase (PubMed:24534845, PubMed:25265334). The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the 6-methylsalicylic acid synthase atX (PubMed:9003280, PubMed:9438344, PubMed:25265334). In the biosynthesis of 6-MSA, atX utilizes one acetyl-CoA and three malonyl-CoAs as its substrates and catalyzes a series of programmed reactions including Claisen condensation, dehydration, reduction, and cyclization to yield 6-MSA (PubMed:9003280, PubMed:9438344, PubMed:25265334). The 6-methylsalicylic acid decarboxylase atA then catalyzes the decarboxylative hydroxylation of 6-MSA to 3-methylcatechol (PubMed:25265334). The next step is the conversion of 3-methylcatechol to terremutin via several oxidation steps involving the cytochrome P450 monooxygenase atE and probably also the cytochrome P450 monooxygenase atG (PubMed:25265334). Lastly, atC is required for the oxidation of terremutin to terreic acid (PubMed:25265334). No function could be assigned to atD yet, although it is involved in the biosynthesis of terreic acid (PubMed:25265334).
Pathways Not Available
Reactions Not Available
GO Classification
Molecular Function
oxidoreductase activity, acting on CH-OH group of donors
lyase activity
flavin adenine dinucleotide binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 63450.735
Theoretical pI Not Available
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q0CJ60
UniProtKB/Swiss-Prot Entry Name ATC_ASPTN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Fujii I, Ono Y, Tada H, Gomi K, Ebizuka Y, Sankawa U: Cloning of the polyketide synthase gene atX from Aspergillus terreus and its identification as the 6-methylsalicylic acid synthase gene by heterologous expression. Mol Gen Genet. 1996 Nov 27;253(1-2):1-10. doi: 10.1007/s004380050289. [PubMed:9003280 ]
  2. Pazoutova S, Linka M, Storkova S, Schwab H: Polyketide synthase gene pksM from Aspergillus terreus expressed during growth phase. Folia Microbiol (Praha). 1997;42(5):419-30. doi: 10.1007/BF02826548. [PubMed:9438344 ]
  3. Kawakami Y, Hartman SE, Kinoshita E, Suzuki H, Kitaura J, Yao L, Inagaki N, Franco A, Hata D, Maeda-Yamamoto M, Fukamachi H, Nagai H, Kawakami T: Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2227-32. doi: 10.1073/pnas.96.5.2227. [PubMed:10051623 ]
  4. Boruta T, Bizukojc M: Culture-based and sequence-based insights into biosynthesis of secondary metabolites by Aspergillus terreus ATCC 20542. J Biotechnol. 2014 Apr 10;175:53-62. doi: 10.1016/j.jbiotec.2014.01.038. Epub 2014 Feb 15. [PubMed:24534845 ]
  5. Guo CJ, Sun WW, Bruno KS, Wang CC: Molecular genetic characterization of terreic acid pathway in Aspergillus terreus. Org Lett. 2014 Oct 17;16(20):5250-3. doi: 10.1021/ol502242a. Epub 2014 Sep 29. [PubMed:25265334 ]
  6. Olesen SH, Ingles DJ, Yang Y, Schonbrunn E: Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin. J Basic Microbiol. 2014 Apr;54(4):322-6. doi: 10.1002/jobm.201200617. Epub 2013 May 20. [PubMed:23686727 ]