Hmdb loader
Identification
HMDB Protein ID HMDBP14459
Secondary Accession Numbers None
Name Latent-transforming growth factor beta-binding protein 1
Synonyms
  1. LTBP-1
  2. Transforming growth factor beta-1-binding protein 1
  3. TGF-beta1-BP-1
Gene Name LTBP1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
Pathways
  • TGF-beta signaling pathway
Reactions Not Available
GO Classification
Biological Process
positive regulation of collagen biosynthetic process
coronary vasculature development
sequestering of TGFbeta in extracellular matrix
aorta development
ventricular septum development
regulation of transforming growth factor beta activation
transforming growth factor beta receptor signaling pathway
Cellular Component
protein-containing complex
cytoplasm
mitochondrion
dendrite
perinuclear region of cytoplasm
microfibril
extracellular region
collagen-containing extracellular matrix
neuronal cell body
large latent transforming growth factor-beta complex
extracellular matrix
Molecular Function
transforming growth factor beta binding
microfibril binding
calcium ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1712
Molecular Weight 186716.115
Theoretical pI 6.019
Pfam Domain Function
Signals
  • 1-23;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8CG19
UniProtKB/Swiss-Prot Entry Name LTBP1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
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  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
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  5. Noguera I, Obata H, Gualandris A, Cowin P, Rifkin DB: Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms. Gene. 2003 Apr 10;308:31-41. doi: 10.1016/s0378-1119(03)00463-3. [PubMed:12711388 ]
  6. Weiskirchen R, Moser M, Gunther K, Weiskirchen S, Gressner AM: The murine latent transforming growth factor-beta binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22. Gene. 2003 Apr 10;308:43-52. doi: 10.1016/s0378-1119(03)00464-5. [PubMed:12711389 ]
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