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Showing Protein Serine-threonine kinase receptor-associated protein (HMDBP14471)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14471
Secondary Accession Numbers None
Name Serine-threonine kinase receptor-associated protein
Synonyms
  1. MAP activator with WD repeats
  2. UNR-interacting protein
  3. WD-40 repeat protein PT-WD
Gene Name STRAP
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
maintenance of gastrointestinal epithelium
negative regulation of epithelial cell proliferation
negative regulation of transcription from RNA polymerase II promoter
spliceosomal snRNP assembly
negative regulation of epithelial cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
neuron differentiation
negative regulation of epithelial to mesenchymal transition
alternative mRNA splicing, via spliceosome
negative regulation of pathway-restricted SMAD protein phosphorylation
Cellular Component
cytosol
cytoplasm
nucleus
SMN complex
SMN-Sm protein complex
Molecular Function
receptor binding
RNA binding
mRNA binding
U2 snRNP binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 350
Molecular Weight 38437.955
Theoretical pI 5.116
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Y3F4
UniProtKB/Swiss-Prot Entry Name STRAP_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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