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Identification
HMDB Protein ID HMDBP14473
Secondary Accession Numbers None
Name Mothers against decapentaplegic homolog 3
Synonyms
  1. MAD homolog 3
  2. Mad3
  3. Mothers against DPP homolog 3
  4. hMAD-3
  5. JV15-2
  6. SMAD family member 3
  7. SMAD 3
  8. Smad3
  9. hSMAD3
Gene Name SMAD3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Pathways
  • Adherens junction
  • AGE-RAGE signaling pathway in diabetic complications
  • Apelin signaling pathway
  • Cell cycle
  • Cellular senescence
  • Chronic myeloid leukemia
  • Colorectal cancer
  • Diabetic cardiomyopathy
  • Endocytosis
  • FoxO signaling pathway
  • Gastric cancer
  • Hepatitis B
  • Hepatocellular carcinoma
  • Hippo signaling pathway
  • Human T-cell leukemia virus 1 infection
  • Inflammatory bowel disease
  • Pancreatic cancer
  • Signaling pathways regulating pluripotency of stem cells
  • TGF-beta signaling pathway
  • Th17 cell differentiation
  • Wnt signaling pathway
Reactions Not Available
GO Classification
Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
activin receptor signaling pathway
embryonic foregut morphogenesis
cell-cell junction organization
embryonic pattern specification
immune system development
negative regulation of cardiac muscle hypertrophy in response to stress
positive regulation of canonical Wnt receptor signaling pathway
negative regulation of lung blood pressure
negative regulation of osteoblast proliferation
wound healing
negative regulation of wound healing
paraxial mesoderm morphogenesis
protein deubiquitination
positive regulation of extracellular matrix assembly
positive regulation of transforming growth factor beta3 production
primary miRNA processing
regulation of epithelial cell proliferation
positive regulation of bone mineralization
regulation of striated muscle tissue development
transdifferentiation
positive regulation of cell migration
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell cycle arrest
negative regulation of apoptotic process
negative regulation of inflammatory response
negative regulation of fat cell differentiation
positive regulation of alkaline phosphatase activity
signal transduction involved in regulation of gene expression
positive regulation of protein import into nucleus
adrenal gland development
SMAD protein signal transduction
osteoblast development
protein stabilization
developmental growth
in utero embryonic development
BMP signaling pathway
anatomical structure morphogenesis
liver development
positive regulation of epithelial to mesenchymal transition
somitogenesis
positive regulation of chondrocyte differentiation
positive regulation of pri-miRNA transcription by RNA polymerase II
positive regulation of nitric oxide biosynthetic process
reduction of cytosolic calcium ion concentration
negative regulation of mitotic cell cycle
regulation of binding
regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-dependent
negative regulation of transcription from RNA polymerase II promoter
endoderm development
cellular response to cytokine stimulus
viral reproduction
immune response
positive regulation of transcription from RNA polymerase II promoter
mesoderm formation
cell differentiation
positive regulation of positive chemotaxis
heart looping
negative regulation of cell growth
embryonic cranial skeleton morphogenesis
pericardium development
thyroid gland development
negative regulation of osteoblast differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
regulation of transforming growth factor beta2 production
lens fiber cell differentiation
negative regulation of protein catabolic process
SMAD protein complex assembly
transforming growth factor beta receptor signaling pathway
nodal signaling pathway
positive regulation of interleukin-1 beta production
positive regulation of gene expression
cellular response to transforming growth factor beta stimulus
response to hypoxia
T cell activation
extrinsic apoptotic signaling pathway
regulation of immune response
ureteric bud development
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
Cellular Component
cytosol
receptor complex
cytoplasm
plasma membrane
nucleus
nucleoplasm
chromatin
heteromeric SMAD protein complex
SMAD protein complex
transcription factor complex
nuclear inner membrane
Molecular Function
ubiquitin binding
protein kinase binding
collagen binding
sequence-specific DNA binding
sequence-specific DNA binding transcription factor activity
co-SMAD binding
phosphatase binding
R-SMAD binding
DNA-binding transcription activator activity, RNA polymerase II-specific
chromatin DNA binding
ubiquitin protein ligase binding
transcription factor binding
zinc ion binding
protein homodimerization activity
I-SMAD binding
transcription coactivator binding
beta-catenin binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
identical protein binding
transcription regulatory region sequence-specific DNA binding
bHLH transcription factor binding
DEAD/H-box RNA helicase binding
glucocorticoid receptor binding
mineralocorticoid receptor binding
transforming growth factor beta receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 425
Molecular Weight 48080.42
Theoretical pI 7.151
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P84022
UniProtKB/Swiss-Prot Entry Name SMAD3_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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