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Identification
HMDB Protein ID HMDBP14490
Secondary Accession Numbers None
Name Zinc finger FYVE domain-containing protein 9
Synonyms
  1. Mothers against decapentaplegic homolog-interacting protein
  2. Novel serine protease
  3. Receptor activation anchor
  4. Smad anchor for receptor activation
  5. Madh-interacting protein
  6. NSP
  7. hSARA
Gene Name ZFYVE9
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
Pathways
  • Endocytosis
  • TGF-beta signaling pathway
Reactions Not Available
GO Classification
Biological Process
endosomal transport
transforming growth factor beta receptor signaling pathway
endocytosis
Cellular Component
cytosol
protein-containing complex
early endosome
early endosome membrane
intracellular membrane-bounded organelle
Molecular Function
metal ion binding
1-phosphatidylinositol binding
protein domain specific binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1425
Molecular Weight 156401.56
Theoretical pI 5.013
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95405
UniProtKB/Swiss-Prot Entry Name ZFYV9_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. [PubMed:14759258 ]
  5. Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massague J, Shi Y: Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science. 2000 Jan 7;287(5450):92-7. [PubMed:10615055 ]
  6. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [PubMed:23186163 ]
  7. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569 ]
  8. Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell. 1998 Dec 11;95(6):779-91. doi: 10.1016/s0092-8674(00)81701-8. [PubMed:9865696 ]
  9. Qin BY, Lam SS, Correia JJ, Lin K: Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. Genes Dev. 2002 Aug 1;16(15):1950-63. doi: 10.1101/gad.1002002. [PubMed:12154125 ]
  10. Meckelein B, Marshall DC, Conn KJ, Pietropaolo M, Van Nostrand W, Abraham CR: Identification of a novel serine protease-like molecule in human brain. Brain Res Mol Brain Res. 1998 Apr;55(2):181-97. doi: 10.1016/s0169-328x(97)00366-5. [PubMed:9582421 ]
  11. Panopoulou E, Gillooly DJ, Wrana JL, Zerial M, Stenmark H, Murphy C, Fotsis T: Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem. 2002 May 17;277(20):18046-52. doi: 10.1074/jbc.M107983200. Epub 2002 Mar 4. [PubMed:11877415 ]
  12. Lin HK, Bergmann S, Pandolfi PP: Cytoplasmic PML function in TGF-beta signalling. Nature. 2004 Sep 9;431(7005):205-11. doi: 10.1038/nature02783. [PubMed:15356634 ]