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Identification
HMDB Protein ID HMDBP14494
Secondary Accession Numbers None
Name TGF-beta receptor type-1
Synonyms
  1. TGFR-1
  2. ESK2
  3. Transforming growth factor-beta receptor type I
  4. TGF-beta receptor type I
  5. TbetaR-I
Gene Name TGFBR1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity).
Pathways
  • Adherens junction
  • AGE-RAGE signaling pathway in diabetic complications
  • Apelin signaling pathway
  • Cellular senescence
  • Chagas disease
  • Chronic myeloid leukemia
  • Colorectal cancer
  • Cytokine-cytokine receptor interaction
  • Diabetic cardiomyopathy
  • Endocytosis
  • FoxO signaling pathway
  • Gastric cancer
  • Hepatitis B
  • Hepatocellular carcinoma
  • Hippo signaling pathway
  • Human T-cell leukemia virus 1 infection
  • MAPK signaling pathway
  • Osteoclast differentiation
  • Pancreatic cancer
  • Relaxin signaling pathway
  • TGF-beta signaling pathway
  • Th17 cell differentiation
Reactions Not Available
GO Classification
Biological Process
activin receptor signaling pathway
peptidyl-serine phosphorylation
ventricular septum morphogenesis
signal transduction
positive regulation of tight junction disassembly
positive regulation of apoptotic process
positive regulation of cell migration
apoptotic process
positive regulation of cell proliferation
negative regulation of apoptotic process
thymus development
palate development
in utero embryonic development
angiogenesis involved in coronary vascular morphogenesis
coronary artery morphogenesis
epicardium morphogenesis
mesenchymal cell differentiation
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of pri-miRNA transcription by RNA polymerase II
parathyroid gland development
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
regulation of cardiac muscle cell proliferation
regulation of epithelial to mesenchymal transition
negative regulation of chondrocyte differentiation
ventricular compact myocardium morphogenesis
ventricular trabecula myocardium morphogenesis
positive regulation of pathway-restricted SMAD protein phosphorylation
lens development in camera-type eye
regulation of protein ubiquitination
positive regulation of epithelial to mesenchymal transition
heart development
epithelial to mesenchymal transition
positive regulation of pri-miRNA transcription by RNA polymerase II
skeletal system morphogenesis
endothelial cell migration
activation of MAPKK activity
germ cell migration
angiogenesis
nervous system development
artery morphogenesis
positive regulation of transcription, DNA-dependent
skeletal system development
endothelial cell activation
positive regulation of protein kinase B signaling cascade
neuron fate commitment
negative regulation of endothelial cell proliferation
regulation of protein binding
positive regulation of cell growth
response to cholesterol
male gonad development
protein phosphorylation
pharyngeal system development
embryonic cranial skeleton morphogenesis
positive regulation of cellular component movement
positive regulation of apoptotic signaling pathway
collagen fibril organization
anterior/posterior pattern specification
positive regulation of SMAD protein signal transduction
kidney development
negative regulation of endothelial cell differentiation
transforming growth factor beta receptor signaling pathway
regulation of gene expression
peptidyl-threonine phosphorylation
cellular response to growth factor stimulus
protein autophosphorylation
positive regulation of gene expression
cell motility
regulation of transcription, DNA-dependent
cellular response to transforming growth factor beta stimulus
positive regulation of endothelial cell proliferation
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
post-embryonic development
intracellular signal transduction
blastocyst development
positive regulation of filopodium assembly
positive regulation of stress fiber assembly
response to estrogen stimulus
Cellular Component
cell surface
membrane raft
protein-containing complex
receptor complex
plasma membrane
nucleus
activin receptor complex
basolateral plasma membrane
caveola
tight junction
apical plasma membrane
membrane
endosome
Molecular Function
protein-containing complex binding
metal ion binding
transforming growth factor beta binding
activin binding
activin receptor activity, type I
transforming growth factor beta receptor activity, type I
transforming growth factor beta-activated receptor activity
ATP binding
ubiquitin protein ligase binding
receptor binding
protein kinase activity
protein serine/threonine kinase activity
I-SMAD binding
type II transforming growth factor beta receptor binding
SMAD binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 503
Molecular Weight 56178.36
Theoretical pI 7.42
Pfam Domain Function
Signals
  • 1-29;
Transmembrane Regions
  • 127-147;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q64729
UniProtKB/Swiss-Prot Entry Name TGFR1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [PubMed:19468303 ]
  3. Tomoda T, Kudoh T, Noma T, Nakazawa A, Muramatsu M, Arai K: Molecular cloning of a mouse counterpart for human TGF-beta type I receptor. Biochem Biophys Res Commun. 1994 Feb 15;198(3):1054-62. doi: 10.1006/bbrc.1994.1150. [PubMed:8117261 ]
  4. Suzuki A, Shioda N, Maeda T, Tada M, Ueno N: A mouse TGF-beta type I receptor that requires type II receptor for ligand binding. Biochem Biophys Res Commun. 1994 Feb 15;198(3):1063-9. doi: 10.1006/bbrc.1994.1151. [PubMed:8117262 ]