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Showing Protein Zinc finger homeobox protein 3 (HMDBP14498)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14498
Secondary Accession Numbers None
Name Zinc finger homeobox protein 3
Synonyms
  1. AT motif-binding factor 1
  2. AT-binding transcription factor 1
  3. Alpha-fetoprotein enhancer-binding protein
  4. Zinc finger homeodomain protein 3
  5. ZFH-3
Gene Name ZFHX3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).
Pathways
  • Signaling pathways regulating pluripotency of stem cells
Reactions Not Available
GO Classification
Biological Process
cell cycle arrest
positive regulation of cell adhesion
muscle organ development
regulation of locomotor rhythm
regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-dependent
negative regulation of transcription from RNA polymerase II promoter
brain development
positive regulation of transcription from RNA polymerase II promoter
regulation of neuron differentiation
positive regulation of myoblast differentiation
response to transforming growth factor beta
regulation of transcription, DNA-dependent
circadian regulation of gene expression
negative regulation of myoblast differentiation
Cellular Component
cytoplasm
nucleus
nucleoplasm
chromatin
nuclear body
transcription factor complex
Molecular Function
DNA-binding transcription repressor activity, RNA polymerase II-specific
sequence-specific DNA binding transcription factor activity
zinc ion binding
enzyme binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 3703
Molecular Weight 404415.73
Theoretical pI 6.202
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q15911
UniProtKB/Swiss-Prot Entry Name ZFHX3_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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  12. Sakata N, Kaneko S, Ikeno S, Miura Y, Nakabayashi H, Dong XY, Dong JT, Tamaoki T, Nakano N, Itoh S: TGF- beta Signaling Cooperates with AT Motif-Binding Factor-1 for Repression of the alpha -Fetoprotein Promoter. J Signal Transduct. 2014;2014:970346. doi: 10.1155/2014/970346. Epub 2014 Jul 3. [PubMed:25105025 ]
  13. Mabuchi M, Kataoka H, Miura Y, Kim TS, Kawaguchi M, Ebi M, Tanaka M, Mori Y, Kubota E, Mizushima T, Shimura T, Mizoshita T, Tanida S, Kamiya T, Asai K, Joh T: Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction. Biochem Biophys Res Commun. 2010 Jul 23;398(2):321-5. doi: 10.1016/j.bbrc.2010.06.090. Epub 2010 Jun 25. [PubMed:20599712 ]
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  15. Morinaga T, Yasuda H, Hashimoto T, Higashio K, Tamaoki T: A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. Mol Cell Biol. 1991 Dec;11(12):6041-9. doi: 10.1128/mcb.11.12.6041-6049.1991. [PubMed:1719379 ]
  16. Berry FB, Miura Y, Mihara K, Kaspar P, Sakata N, Hashimoto-Tamaoki T, Tamaoki T: Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. J Biol Chem. 2001 Jul 6;276(27):25057-65. doi: 10.1074/jbc.M010378200. Epub 2001 Apr 18. [PubMed:11312261 ]
  17. Nojiri S, Joh T, Miura Y, Sakata N, Nomura T, Nakao H, Sobue S, Ohara H, Asai K, Ito M: ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. Biochem Biophys Res Commun. 2004 Jan 30;314(1):97-103. doi: 10.1016/j.bbrc.2003.12.054. [PubMed:14715251 ]
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  22. Dong XY, Fu X, Fan S, Guo P, Su D, Dong JT: Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP. Biochem J. 2012 Jun 15;444(3):581-90. doi: 10.1042/BJ20111890. [PubMed:22452784 ]
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  24. Sun X, Li J, Dong FN, Dong JT: Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. PLoS One. 2014 Mar 20;9(3):e92746. doi: 10.1371/journal.pone.0092746. eCollection 2014. [PubMed:24651376 ]