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Showing Protein Mothers against decapentaplegic homolog 2 (HMDBP14505)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14505
Secondary Accession Numbers None
Name Mothers against decapentaplegic homolog 2
Synonyms
  1. MAD homolog 2
  2. Mothers against DPP homolog 2
  3. Mad-related protein 2
  4. SMAD family member 2
  5. mMad2
  6. SMAD 2
  7. Smad2
Gene Name SMAD2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Pathways
  • AGE-RAGE signaling pathway in diabetic complications
  • Apelin signaling pathway
  • Cell cycle
  • Cellular senescence
  • Chagas disease
  • Colorectal cancer
  • Diabetic cardiomyopathy
  • Endocytosis
  • Gastric cancer
  • Hepatocellular carcinoma
  • Hippo signaling pathway
  • Human T-cell leukemia virus 1 infection
  • Inflammatory bowel disease
  • Pancreatic cancer
  • Proteoglycans in cancer
  • Relaxin signaling pathway
  • Signaling pathways regulating pluripotency of stem cells
  • TGF-beta signaling pathway
  • Th17 cell differentiation
Reactions Not Available
GO Classification
Biological Process
activin receptor signaling pathway
gastrulation
embryonic foregut morphogenesis
embryonic pattern specification
wound healing
paraxial mesoderm morphogenesis
organ growth
signal transduction involved in regulation of gene expression
pattern specification process
adrenal gland development
SMAD protein signal transduction
developmental growth
in utero embryonic development
BMP signaling pathway
anatomical structure morphogenesis
positive regulation of epithelial to mesenchymal transition
heart development
regulation of binding
zygotic specification of dorsal/ventral axis
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
negative regulation of transcription, DNA-dependent
positive regulation of transcription, DNA-dependent
endoderm development
positive regulation of transcription from RNA polymerase II promoter
mesoderm formation
cell differentiation
cell fate commitment
insulin secretion
response to cholesterol
response to glucose stimulus
protein phosphorylation
embryonic cranial skeleton morphogenesis
positive regulation of BMP signaling pathway
pericardium development
anterior/posterior pattern specification
regulation of transforming growth factor beta receptor signaling pathway
secondary palate development
endoderm formation
SMAD protein complex assembly
lung development
transforming growth factor beta receptor signaling pathway
nodal signaling pathway
negative regulation of cell proliferation
pancreas development
positive regulation of gene expression
negative regulation of gene expression
common-partner SMAD protein phosphorylation
post-embryonic development
ureteric bud development
intracellular signal transduction
Cellular Component
protein-containing complex
cytoplasm
nucleus
nucleoplasm
chromatin
activin responsive factor complex
heteromeric SMAD protein complex
SMAD protein complex
transcription factor complex
Molecular Function
metal ion binding
sequence-specific DNA binding transcription factor activity
co-SMAD binding
phosphatase binding
R-SMAD binding
DNA-binding transcription activator activity, RNA polymerase II-specific
tau protein binding
ubiquitin protein ligase binding
transcription factor binding
disordered domain specific binding
double-stranded DNA binding
chromatin binding
activating transcription factor binding
I-SMAD binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
SMAD binding
type I transforming growth factor beta receptor binding
transforming growth factor beta receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 467
Molecular Weight 52265.7
Theoretical pI 6.577
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q62432
UniProtKB/Swiss-Prot Entry Name SMAD2_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Kuratomi G, Komuro A, Goto K, Shinozaki M, Miyazawa K, Miyazono K, Imamura T: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Biochem J. 2005 Mar 15;386(Pt 3):461-70. [PubMed:15496141 ]
  4. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  5. Jiao K, Zhou Y, Hogan BL: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Mol Cell Biol. 2002 Nov;22(21):7633-44. doi: 10.1128/MCB.22.21.7633-7644.2002. [PubMed:12370310 ]
  6. Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J, Wrana JL: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. Dev Cell. 2010 Dec 14;19(6):831-44. doi: 10.1016/j.devcel.2010.11.012. [PubMed:21145499 ]
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  10. Bernard DJ: Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells. Mol Endocrinol. 2004 Mar;18(3):606-23. doi: 10.1210/me.2003-0264. Epub 2003 Dec 30. [PubMed:14701940 ]
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