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Showing Protein Bone morphogenetic protein 6 (HMDBP14531)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14531
Secondary Accession Numbers None
Name Bone morphogenetic protein 6
Synonyms
  1. BMP-6
  2. VG-1-related protein
  3. VG-1-R
  4. VGR-1
Gene Name BMP6
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (PubMed:31019025). Plays also an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B (PubMed:18070108). In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (PubMed:33021694).
Pathways
  • Cytokine-cytokine receptor interaction
  • Hippo signaling pathway
  • Ovarian steroidogenesis
  • TGF-beta signaling pathway
Reactions Not Available
GO Classification
Biological Process
positive regulation of bone mineralization
positive regulation of cell proliferation
response to retinoic acid
SMAD protein signal transduction
inflammatory response
positive regulation of neuron differentiation
positive regulation of protein secretion
response to magnesium ion
BMP signaling pathway
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of endothelial cell differentiation
cellular iron ion homeostasis
positive regulation of chondrocyte differentiation
osteoblast differentiation
positive regulation of peptidyl-tyrosine phosphorylation
response to glucocorticoid stimulus
positive regulation of lipopolysaccharide-mediated signaling pathway
skeletal system development
negative regulation of transcription from RNA polymerase II promoter
immune response
positive regulation of transcription from RNA polymerase II promoter
eye development
cellular response to iron ion
multicellular organismal iron ion homeostasis
negative regulation of adherens junction organization
positive regulation of osteoblast differentiation
negative regulation of cell-cell adhesion mediated by cadherin
positive regulation of aldosterone biosynthetic process
positive regulation of aldosterone secretion
male genitalia development
type B pancreatic cell development
response to activity
cartilage development
positive regulation of epithelial cell proliferation
positive regulation of SMAD protein signal transduction
kidney development
cellular response to mechanical stimulus
positive regulation of vascular permeability
positive regulation of gene expression
positive regulation of endothelial cell proliferation
cellular response to BMP stimulus
endochondral ossification
Cellular Component
cytoplasm
vesicle
extracellular space
Molecular Function
BMP receptor binding
growth factor activity
cytokine activity
protein heterodimerization activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 513
Molecular Weight 57225.22
Theoretical pI 8.106
Pfam Domain Function
Signals
  • 1-20;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P22004
UniProtKB/Swiss-Prot Entry Name BMP6_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [PubMed:14574404 ]
  2. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  3. Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9843-7. [PubMed:2263636 ]
  4. Allendorph GP, Isaacs MJ, Kawakami Y, Izpisua Belmonte JC, Choe S: BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry. 2007 Oct 30;46(43):12238-47. doi: 10.1021/bi700907k. Epub 2007 Oct 9. [PubMed:17924656 ]
  5. Pulkkinen HH, Kiema M, Lappalainen JP, Toropainen A, Beter M, Tirronen A, Holappa L, Niskanen H, Kaikkonen MU, Yla-Herttuala S, Laakkonen JP: BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF. Angiogenesis. 2021 Feb;24(1):129-144. doi: 10.1007/s10456-020-09748-4. Epub 2020 Oct 6. [PubMed:33021694 ]
  6. Saremba S, Nickel J, Seher A, Kotzsch A, Sebald W, Mueller TD: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand. FEBS J. 2008 Jan;275(1):172-83. doi: 10.1111/j.1742-4658.2007.06187.x. Epub 2007 Dec 6. [PubMed:18070108 ]
  7. Seeherman HJ, Berasi SP, Brown CT, Martinez RX, Juo ZS, Jelinsky S, Cain MJ, Grode J, Tumelty KE, Bohner M, Grinberg O, Orr N, Shoseyov O, Eyckmans J, Chen C, Morales PR, Wilson CG, Vanderploeg EJ, Wozney JM: A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Sci Transl Med. 2019 Apr 24;11(489). pii: 11/489/eaar4953. doi: 10.1126/scitranslmed.aar4953. [PubMed:31019025 ]