Hmdb loader

Showing Protein Proto-oncogene c-Fos (HMDBP14541)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14541
Secondary Accession Numbers None
Name Proto-oncogene c-Fos
Synonyms
  1. Cellular oncogene fos
  2. G0/G1 switch regulatory protein 7
Gene Name FOS
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Pathways
  • Amphetamine addiction
  • Apoptosis
  • B cell receptor signaling pathway
  • Breast cancer
  • cAMP signaling pathway
  • Chagas disease
  • Chemical carcinogenesis - reactive oxygen species
  • Chemical carcinogenesis - receptor activation
  • Choline metabolism in cancer
  • Cholinergic synapse
  • Circadian entrainment
  • Colorectal cancer
  • Coronavirus disease - COVID-19
  • Dopaminergic synapse
  • Endocrine resistance
  • Estrogen signaling pathway
  • Fluid shear stress and atherosclerosis
  • Growth hormone synthesis, secretion and action
  • Hepatitis B
  • Human immunodeficiency virus 1 infection
  • Human T-cell leukemia virus 1 infection
  • IL-17 signaling pathway
  • Kaposi sarcoma-associated herpesvirus infection
  • Leishmaniasis
  • Lipid and atherosclerosis
  • MAPK signaling pathway
  • Measles
  • Non-alcoholic fatty liver disease
  • Osteoclast differentiation
  • Oxytocin signaling pathway
  • Parathyroid hormone synthesis, secretion and action
  • Pathogenic Escherichia coli infection
  • PD-L1 expression and PD-1 checkpoint pathway in cancer
  • Pertussis
  • Prolactin signaling pathway
  • Relaxin signaling pathway
  • Rheumatoid arthritis
  • Salmonella infection
  • T cell receptor signaling pathway
  • Th1 and Th2 cell differentiation
  • Th17 cell differentiation
  • TNF signaling pathway
  • Toll-like receptor signaling pathway
  • Yersinia infection
Reactions Not Available
GO Classification
Biological Process
skeletal muscle cell differentiation
transcription from RNA polymerase II promoter
female pregnancy
response to gravity
cellular response to calcium ion
response to progesterone stimulus
cellular response to extracellular stimulus
Fc-epsilon receptor signaling pathway
cellular response to hormone stimulus
response to light stimulus
response to lipopolysaccharide
sleep
SMAD protein signal transduction
conditioned taste aversion
inflammatory response
response to drug
positive regulation of pri-miRNA transcription by RNA polymerase II
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
cellular response to cadmium ion
cellular response to reactive oxygen species
cytokine-mediated signaling pathway
positive regulation of osteoclast differentiation
positive regulation of neuron death
aging
response to corticosterone stimulus
transforming growth factor beta receptor signaling pathway
response to toxin
response to muscle stretch
response to immobilization stress
regulation of sequence-specific DNA binding transcription factor activity
DNA methylation
response to cAMP
response to cold
Cellular Component
cytosol
endoplasmic reticulum
nucleus
transcription factor AP-1 complex
nucleoplasm
protein-DNA complex
chromatin
membrane
neuron projection
Molecular Function
protein-containing complex binding
sequence-specific DNA binding transcription factor activity
R-SMAD binding
RNA polymerase II core promoter sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription factor binding
chromatin binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
sequence-specific double-stranded DNA binding
transcription regulatory region sequence-specific DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 380
Molecular Weight 40694.855
Theoretical pI 4.861
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P01100
UniProtKB/Swiss-Prot Entry Name FOS_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  4. Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. [PubMed:12508121 ]
  5. Glover JN, Harrison SC: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature. 1995 Jan 19;373(6511):257-61. [PubMed:7816143 ]
  6. van Straaten F, Muller R, Curran T, Van Beveren C, Verma IM: Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. Proc Natl Acad Sci U S A. 1983 Jun;80(11):3183-7. [PubMed:6574479 ]
  7. Roux P, Verrier B, Klein B, Niccolino M, Marty L, Alexandre C, Piechaczyk M: Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells. Oncogene. 1991 Nov;6(11):2155-60. [PubMed:1658710 ]
  8. Hai TW, Liu F, Coukos WJ, Green MR: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 1989 Dec;3(12B):2083-90. [PubMed:2516827 ]
  9. Nakabeppu Y, Nathans D: The basic region of Fos mediates specific DNA binding. EMBO J. 1989 Dec 1;8(12):3833-41. [PubMed:2511004 ]
  10. Okazaki K, Sagata N: The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. EMBO J. 1995 Oct 16;14(20):5048-59. [PubMed:7588633 ]
  11. Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel-Encontre I, Piechaczyk M: Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol Cell Biol. 2005 Aug;25(16):6964-79. [PubMed:16055710 ]
  12. Jakobs A, Himstedt F, Funk M, Korn B, Gaestel M, Niedenthal R: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. Nucleic Acids Res. 2007;35(17):e109. Epub 2007 Aug 20. [PubMed:17709345 ]
  13. Hendriks IA, Lyon D, Young C, Jensen LJ, Vertegaal AC, Nielsen ML: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat Struct Mol Biol. 2017 Mar;24(3):325-336. doi: 10.1038/nsmb.3366. Epub 2017 Jan 23. [PubMed:28112733 ]
  14. Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC: Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol. 2014 Oct;21(10):927-36. doi: 10.1038/nsmb.2890. Epub 2014 Sep 14. [PubMed:25218447 ]
  15. Hendriks IA, Treffers LW, Verlaan-de Vries M, Olsen JV, Vertegaal ACO: SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. Cell Rep. 2015 Mar 17;10(10):1778-1791. doi: 10.1016/j.celrep.2015.02.033. Epub 2015 Mar 12. [PubMed:25772364 ]
  16. Zhang Y, Feng XH, Derynck R: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 1998 Aug 27;394(6696):909-13. doi: 10.1038/29814. [PubMed:9732876 ]
  17. Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J: Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol. 2002 Aug;4(8):556-64. doi: 10.1038/ncb822. [PubMed:12134156 ]
  18. Portal MM, Ferrero GO, Caputto BL: N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation. Oncogene. 2007 May 24;26(24):3551-8. doi: 10.1038/sj.onc.1210137. Epub 2006 Dec 11. [PubMed:17160021 ]
  19. Ferrero GO, Velazquez FN, Caputto BL: The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity. Oncogene. 2012 Jul 12;31(28):3381-91. doi: 10.1038/onc.2011.510. Epub 2011 Nov 21. [PubMed:22105363 ]