Identification |
HMDB Protein ID
| HMDBP14544 |
Secondary Accession Numbers
| None |
Name
| Forkhead box protein H1 |
Synonyms
|
- Forkhead activin signal transducer 1
- Forkhead activin signal transducer 2
- Fast-1
- hFAST-1
- Fast-2
|
Gene Name
| FOXH1 |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
negative regulation of sequence-specific DNA binding transcription factor activity |
secondary heart field specification |
axial mesoderm development |
embryonic heart tube anterior/posterior pattern specification |
ventricular trabecula myocardium morphogenesis |
cardiac right ventricle morphogenesis |
positive regulation of transcription, DNA-dependent |
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
negative regulation of transcription from RNA polymerase II promoter |
cellular response to cytokine stimulus |
positive regulation of transcription from RNA polymerase II promoter |
aorta morphogenesis |
heart looping |
outflow tract morphogenesis |
negative regulation of intracellular estrogen receptor signaling pathway |
transforming growth factor beta receptor signaling pathway |
negative regulation of androgen receptor signaling pathway |
Cellular Component |
nucleus |
nucleoplasm |
chromatin |
activin responsive factor complex |
transcription factor complex |
Molecular Function |
sequence-specific DNA binding |
sequence-specific DNA binding transcription factor activity |
co-SMAD binding |
R-SMAD binding |
DNA-binding transcription activator activity, RNA polymerase II-specific |
androgen receptor binding |
protein domain specific binding |
DNA-binding transcription factor activity, RNA polymerase II-specific |
core promoter proximal region sequence-specific DNA binding |
transcription regulatory region sequence-specific DNA binding |
SMAD binding |
bHLH transcription factor binding |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 365 |
Molecular Weight
| 39256.61 |
Theoretical pI
| 9.514 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| O75593 |
UniProtKB/Swiss-Prot Entry Name
| FOXH1_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B: Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul;2(1):121-7. [PubMed:9702198 ]
|