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Identification
HMDB Protein ID HMDBP14545
Secondary Accession Numbers None
Name F-box only protein 11
Synonyms
  1. Protein arginine N-methyltransferase 9
  2. Vitiligo-associated protein 1
  3. VIT-1
Gene Name FBXO11
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Pathways
  • protein ubiquitination
Reactions Not Available
GO Classification
Biological Process
sensory perception of sound
protein polyubiquitination
cellular protein modification process
ubiquitin-dependent protein catabolic process
post-translational protein modification
regulation of apoptotic process
protein ubiquitination
Cellular Component
cytosol
chromosome
cytoplasm
nucleolus
nucleus
nucleoplasm
ubiquitin ligase complex
Molecular Function
protein-arginine N-methyltransferase activity
ubiquitin-protein ligase activity
zinc ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 927
Molecular Weight 103584.42
Theoretical pI 6.995
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q86XK2
UniProtKB/Swiss-Prot Entry Name FBX11_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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