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Showing Protein Zinc finger and BTB domain-containing protein 7A (HMDBP14564)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14564
Secondary Accession Numbers None
Name Zinc finger and BTB domain-containing protein 7A
Synonyms
  1. Leukemia/lymphoma-related factor
  2. POZ and Krueppel erythroid myeloid ontogenic factor
  3. POK erythroid myeloid ontogenic factor
  4. Pokemon
Gene Name ZBTB7A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:15337766, PubMed:15662416, PubMed:17495164, PubMed:26816381, PubMed:29813070). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:15337766, PubMed:15662416, PubMed:26816381, PubMed:29813070). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (By similarity). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (PubMed:29813070). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (By similarity). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (By similarity). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (PubMed:15662416). Efficiently abrogates E2F1-dependent CDKN2A transactivation (PubMed:15662416). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (PubMed:15337766). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (By similarity). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (PubMed:17495164). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (PubMed:17495164). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (PubMed:26446488). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (PubMed:26446488). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
fat cell differentiation
chromatin organization
regulation of glycolysis
double-strand break repair via classical nonhomologous end joining
regulation of osteoclast differentiation
regulation of transcription regulatory region DNA binding
B cell differentiation
erythrocyte maturation
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-dependent
regulation of alternative mRNA splicing, via spliceosome
negative regulation of transcription from RNA polymerase II promoter
regulation of apoptotic process
negative regulation of Notch signaling pathway
cartilage development
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
regulation of transcription, DNA-dependent
transcription, DNA-dependent
regulation of sequence-specific DNA binding transcription factor activity
negative regulation of androgen receptor signaling pathway
protein localization to nucleus
Cellular Component
cytoplasm
nucleus
DNA-dependent protein kinase complex
NuRD complex
Molecular Function
metal ion binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
transcription corepressor binding
sequence-specific DNA binding
sequence-specific DNA binding transcription factor activity
histone acetyltransferase binding
androgen receptor binding
activating transcription factor binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific double-stranded DNA binding
DNA binding
SMAD binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 569
Molecular Weight 60280.27
Theoretical pI 5.119
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O88939
UniProtKB/Swiss-Prot Entry Name ZBT7A_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  5. Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A: Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. Oncogene. 1999 Jan 14;18(2):365-75. doi: 10.1038/sj.onc.1202332. [PubMed:9927193 ]
  6. Laudes M, Christodoulides C, Sewter C, Rochford JJ, Considine RV, Sethi JK, Vidal-Puig A, O'Rahilly S: Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis. J Biol Chem. 2004 Mar 19;279(12):11711-8. doi: 10.1074/jbc.M310240200. Epub 2003 Dec 30. [PubMed:14701838 ]
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  9. Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T: Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science. 2016 Jan 15;351(6270):285-9. doi: 10.1126/science.aad3312. [PubMed:26816381 ]
  10. Ramos Pittol JM, Oruba A, Mittler G, Saccani S, van Essen D: Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors. PLoS Biol. 2018 May 29;16(5):e2004526. doi: 10.1371/journal.pbio.2004526. eCollection 2018 May. [PubMed:29813070 ]
  11. Liu CJ, Prazak L, Fajardo M, Yu S, Tyagi N, Di Cesare PE: Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. J Biol Chem. 2004 Nov 5;279(45):47081-91. doi: 10.1074/jbc.M405288200. Epub 2004 Aug 26. [PubMed:15337766 ]
  12. Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science. 2007 May 11;316(5826):860-6. doi: 10.1126/science.1140881. [PubMed:17495164 ]