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Identification
HMDB Protein ID HMDBP14565
Secondary Accession Numbers None
Name Latent-transforming growth factor beta-binding protein 1
Synonyms
  1. LTBP-1
  2. Transforming growth factor beta-1-binding protein 1
  3. TGF-beta1-BP-1
Gene Name LTBP1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).
Pathways
  • TGF-beta signaling pathway
Reactions Not Available
GO Classification
Biological Process
post-translational protein modification
cellular protein metabolic process
sequestering of TGFbeta in extracellular matrix
regulation of transforming growth factor beta activation
Cellular Component
protein-containing complex
endoplasmic reticulum lumen
microfibril
extracellular region
collagen-containing extracellular matrix
extracellular matrix
Molecular Function
transforming growth factor beta binding
transforming growth factor beta-activated receptor activity
microfibril binding
calcium ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1721
Molecular Weight 186794.93
Theoretical pI 5.962
Pfam Domain Function
Signals
  • 1-23;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q14766
UniProtKB/Swiss-Prot Entry Name LTBP1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A: Phosphoproteome of resting human platelets. J Proteome Res. 2008 Feb;7(2):526-34. Epub 2007 Dec 19. [PubMed:18088087 ]
  4. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569 ]
  5. Sasaki T, Hanisch FG, Deutzmann R, Sakai LY, Sakuma T, Miyamoto T, Yamamoto T, Hannappel E, Chu ML, Lanig H, von der Mark K: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa. Matrix Biol. 2016 Dec;56:132-149. doi: 10.1016/j.matbio.2016.06.003. Epub 2016 Jun 23. [PubMed:27339457 ]
  6. Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE: A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell. 2015 Jun 18;161(7):1619-32. doi: 10.1016/j.cell.2015.05.028. [PubMed:26091039 ]
  7. Saharinen J, Hyytiainen M, Taipale J, Keski-Oja J: Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. Cytokine Growth Factor Rev. 1999 Jun;10(2):99-117. doi: 10.1016/s1359-6101(99)00010-6. [PubMed:10743502 ]
  8. Saharinen J, Keski-Oja J: Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. Mol Biol Cell. 2000 Aug;11(8):2691-704. doi: 10.1091/mbc.11.8.2691. [PubMed:10930463 ]
  9. Oklu R, Hesketh R: The latent transforming growth factor beta binding protein (LTBP) family. Biochem J. 2000 Dec 15;352 Pt 3:601-10. [PubMed:11104663 ]
  10. Koli K, Hyytiainen M, Ryynanen MJ, Keski-Oja J: Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts. Exp Cell Res. 2005 Nov 1;310(2):370-82. doi: 10.1016/j.yexcr.2005.08.008. Epub 2005 Sep 12. [PubMed:16157329 ]
  11. Wang R, Zhu J, Dong X, Shi M, Lu C, Springer TA: GARP regulates the bioavailability and activation of TGFbeta. Mol Biol Cell. 2012 Mar;23(6):1129-39. doi: 10.1091/mbc.E11-12-1018. Epub 2012 Jan 25. [PubMed:22278742 ]
  12. Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH: TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Cell. 1990 Jun 15;61(6):1051-61. doi: 10.1016/0092-8674(90)90069-q. [PubMed:2350783 ]
  13. Olofsson A, Ichijo H, Moren A, ten Dijke P, Miyazono K, Heldin CH: Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix. J Biol Chem. 1995 Dec 29;270(52):31294-7. doi: 10.1074/jbc.270.52.31294. [PubMed:8537398 ]
  14. Miyazono K, Olofsson A, Colosetti P, Heldin CH: A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO J. 1991 May;10(5):1091-101. [PubMed:2022183 ]
  15. Saharinen J, Taipale J, Keski-Oja J: Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. EMBO J. 1996 Jan 15;15(2):245-53. [PubMed:8617200 ]
  16. Rudd PM, Downing AK, Cadene M, Harvey DJ, Wormald MR, Weir I, Dwek RA, Rifkin DB, Gleizes PE: Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells. Biochemistry. 2000 Feb 22;39(7):1596-603. doi: 10.1021/bi9918285. [PubMed:10677208 ]
  17. Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY: Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem. 2003 Jan 24;278(4):2750-7. doi: 10.1074/jbc.M209256200. Epub 2002 Nov 11. [PubMed:12429738 ]
  18. Annes JP, Chen Y, Munger JS, Rifkin DB: Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol. 2004 Jun 7;165(5):723-34. doi: 10.1083/jcb.200312172. [PubMed:15184403 ]
  19. Chen Y, Ali T, Todorovic V, O'leary JM, Kristina Downing A, Rifkin DB: Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. J Mol Biol. 2005 Jan 7;345(1):175-86. doi: 10.1016/j.jmb.2004.10.039. [PubMed:15567420 ]
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  21. Lack J, O'Leary JM, Knott V, Yuan X, Rifkin DB, Handford PA, Downing AK: Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta. J Mol Biol. 2003 Nov 21;334(2):281-91. doi: 10.1016/j.jmb.2003.09.053. [PubMed:14607119 ]