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Identification |
HMDB Protein ID
| HMDBP14594 |
Secondary Accession Numbers
| None |
Name
| Acidic phospholipase A2 Tgc-E6 |
Synonyms
|
- svPLA2
- Phosphatidylcholine 2-acylhydrolase
|
Gene Name
| Not Available |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Snake venom phospholipase A2 (PLA2) that inhibits the ADP-(IC(50)=272 nM) and collagen-induced (IC(50)=518 nM) human platelet aggregation in platelet rich plasma. Exhibits very high hydrolytic activities toward the synthetic lecithin, and prefers the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
phospholipid metabolic process |
lipid catabolic process |
arachidonic acid secretion |
envenomation resulting in negative regulation of platelet aggregation in other organism |
Cellular Component |
extracellular region |
host extracellular space |
Molecular Function |
phospholipase A2 activity |
toxin activity |
calcium ion binding |
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 15688.81 |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| A8E2V8 |
UniProtKB/Swiss-Prot Entry Name
| PA2A_TRIGS |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Tsai IH, Tsai TS, Wang YM, Tu MC, Chang HC: Cloning and characterization of Trimeresurus gracilis venom phospholipases A(2): comparison with Ovophis okinavensis venom and the systematic implications. Toxicon. 2012 Jan;59(1):151-7. doi: 10.1016/j.toxicon.2011.10.016. Epub 2011 Nov 17. [PubMed:22115990 ]
|