| Identification |
|---|
| HMDB Protein ID
| HMDBP14597 |
| Secondary Accession Numbers
| None |
| Name
| Acidic phospholipase A2 Ts-A6 |
| Synonyms
|
- svPLA2
- CTs-A6
- Phosphatidylcholine 2-acylhydrolase
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Snake venom phospholipase A2 (PLA2) that shows a moderate inhibition of ADP-induced human platelet aggregation when tested on platelet rich plasma. Exhibits high hydrolytic activities and prefers the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| phospholipid metabolic process |
| lipid catabolic process |
| arachidonic acid secretion |
| Cellular Component |
| extracellular region |
| Molecular Function |
| phospholipase A2 activity |
| toxin activity |
| calcium ion binding |
| phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
| phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 15706.615 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6H3C8 |
| UniProtKB/Swiss-Prot Entry Name
| PA2AF_TRIST |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tsai IH, Wang YM, Chen YH, Tsai TS, Tu MC: Venom phospholipases A2 of bamboo viper (Trimeresurus stejnegeri): molecular characterization, geographic variations and evidence of multiple ancestries. Biochem J. 2004 Jan 1;377(Pt 1):215-23. doi: 10.1042/BJ20030818. [PubMed:12959640 ]
|
