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Showing Protein Candidapepsin-5 (HMDBP14602)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14602
Secondary Accession Numbers None
Name Candidapepsin-5
Synonyms
  1. ACP 5
  2. Aspartate protease 5
  3. Secreted aspartic protease 5
Gene Name SAP5
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
single-species biofilm formation
proteolysis
pathogenesis
fungal-type cell wall organization
Cellular Component
extracellular region
fungal-type cell wall
fungal biofilm matrix
Molecular Function
aspartic-type endopeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 418
Molecular Weight 45648.085
Theoretical pI 6.381
Pfam Domain Function
Signals
  • 1-18;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P43094
UniProtKB/Swiss-Prot Entry Name CARP5_CANAL
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. doi: 10.1073/pnas.0401648101. Epub 2004 May 3. [PubMed:15123810 ]
  2. van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT: Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52. [PubMed:17419877 ]
  3. Muzzey D, Schwartz K, Weissman JS, Sherlock G: Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97. [PubMed:24025428 ]
  4. Schaller M, Januschke E, Schackert C, Woerle B, Korting HC: Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo. J Med Microbiol. 2001 Aug;50(8):743-747. doi: 10.1099/0022-1317-50-8-743. [PubMed:11478679 ]
  5. Aoki W, Kitahara N, Miura N, Morisaka H, Yamamoto Y, Kuroda K, Ueda M: Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans. J Biochem. 2011 Oct;150(4):431-8. doi: 10.1093/jb/mvr073. Epub 2011 Jun 5. [PubMed:21646240 ]
  6. Staniszewska M, Bondaryk M, Siennicka K, Kurek A, Orlowski J, Schaller M, Kurzatkowski W: In vitro study of secreted aspartyl proteinases Sap1 to Sap3 and Sap4 to Sap6 expression in Candida albicans pleomorphic forms. Pol J Microbiol. 2012;61(4):247-56. [PubMed:23484407 ]
  7. Bochenska O, Rapala-Kozik M, Wolak N, Bras G, Kozik A, Dubin A, Aoki W, Ueda M, Mak P: Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin. Peptides. 2013 Oct;48:49-58. doi: 10.1016/j.peptides.2013.07.023. Epub 2013 Aug 6. [PubMed:23927842 ]
  8. Monod M, Togni G, Hube B, Sanglard D: Multiplicity of genes encoding secreted aspartic proteinases in Candida species. Mol Microbiol. 1994 Jul;13(2):357-68. doi: 10.1111/j.1365-2958.1994.tb00429.x. [PubMed:7984113 ]
  9. Taylor BN, Staib P, Binder A, Biesemeier A, Sehnal M, Rollinghoff M, Morschhauser J, Schroppel K: Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection. Infect Immun. 2005 Mar;73(3):1828-35. doi: 10.1128/IAI.73.3.1828-1835.2005. [PubMed:15731084 ]
  10. Cadicamo CD, Mortier J, Wolber G, Hell M, Heinrich IE, Michel D, Semlin L, Berger U, Korting HC, Holtje HD, Koksch B, Borelli C: Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans. Biochem Pharmacol. 2013 Apr 1;85(7):881-7. doi: 10.1016/j.bcp.2012.12.008. Epub 2012 Dec 21. [PubMed:23262278 ]