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Showing Protein Candidapepsin-6 (HMDBP14605)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14605
Secondary Accession Numbers None
Name Candidapepsin-6
Synonyms
  1. ACP 6
  2. Aspartate protease 6
  3. Secreted aspartic protease 6
Gene Name SAP6
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Activates host systemic immunity and induces host inflammatory cytokine production in a proteolytic activity-independent way. Contributes to corneal pathogenicity. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
induction by symbiont of defense-related host calcium ion flux
protein metabolic process
signal peptide processing
single-species biofilm formation
proteolysis
pathogenesis
fungal-type cell wall organization
induction by symbiont of host defense response
activation of immune response
Cellular Component
extracellular region
fungal-type cell wall
fungal biofilm matrix
Molecular Function
aspartic-type endopeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 418
Molecular Weight 45431.935
Theoretical pI 8.038
Pfam Domain Function
Signals
  • 1-18;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q5AC08
UniProtKB/Swiss-Prot Entry Name CARP6_CANAL
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. doi: 10.1073/pnas.0401648101. Epub 2004 May 3. [PubMed:15123810 ]
  2. van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT: Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52. [PubMed:17419877 ]
  3. Muzzey D, Schwartz K, Weissman JS, Sherlock G: Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97. [PubMed:24025428 ]
  4. Smolenski G, Sullivan PA, Cutfield SM, Cutfield JF: Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes. Microbiology (Reading). 1997 Feb;143 ( Pt 2):349-356. doi: 10.1099/00221287-143-2-349. [PubMed:9043112 ]
  5. Schaller M, Januschke E, Schackert C, Woerle B, Korting HC: Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo. J Med Microbiol. 2001 Aug;50(8):743-747. doi: 10.1099/0022-1317-50-8-743. [PubMed:11478679 ]
  6. Pietrella D, Rachini A, Pandey N, Schild L, Netea M, Bistoni F, Hube B, Vecchiarelli A: The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity. Infect Immun. 2010 Nov;78(11):4754-62. doi: 10.1128/IAI.00789-10. Epub 2010 Aug 16. [PubMed:20713630 ]
  7. Aoki W, Kitahara N, Miura N, Morisaka H, Yamamoto Y, Kuroda K, Ueda M: Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans. J Biochem. 2011 Oct;150(4):431-8. doi: 10.1093/jb/mvr073. Epub 2011 Jun 5. [PubMed:21646240 ]
  8. Ramage G, Coco B, Sherry L, Bagg J, Lappin DF: In vitro Candida albicans biofilm induced proteinase activity and SAP8 expression correlates with in vivo denture stomatitis severity. Mycopathologia. 2012 Jul;174(1):11-19. doi: 10.1007/s11046-012-9522-2. [PubMed:22302440 ]
  9. Staniszewska M, Bondaryk M, Siennicka K, Kurek A, Orlowski J, Schaller M, Kurzatkowski W: In vitro study of secreted aspartyl proteinases Sap1 to Sap3 and Sap4 to Sap6 expression in Candida albicans pleomorphic forms. Pol J Microbiol. 2012;61(4):247-56. [PubMed:23484407 ]
  10. Bochenska O, Rapala-Kozik M, Wolak N, Bras G, Kozik A, Dubin A, Aoki W, Ueda M, Mak P: Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin. Peptides. 2013 Oct;48:49-58. doi: 10.1016/j.peptides.2013.07.023. Epub 2013 Aug 6. [PubMed:23927842 ]
  11. Cadicamo CD, Mortier J, Wolber G, Hell M, Heinrich IE, Michel D, Semlin L, Berger U, Korting HC, Holtje HD, Koksch B, Borelli C: Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans. Biochem Pharmacol. 2013 Apr 1;85(7):881-7. doi: 10.1016/j.bcp.2012.12.008. Epub 2012 Dec 21. [PubMed:23262278 ]
  12. Felk A, Kretschmar M, Albrecht A, Schaller M, Beinhauer S, Nichterlein T, Sanglard D, Korting HC, Schafer W, Hube B: Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs. Infect Immun. 2002 Jul;70(7):3689-700. doi: 10.1128/IAI.70.7.3689-3700.2002. [PubMed:12065511 ]
  13. Jackson BE, Wilhelmus KR, Hube B: The role of secreted aspartyl proteinases in Candida albicans keratitis. Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3559-65. doi: 10.1167/iovs.07-0114. [PubMed:17652724 ]
  14. Glittenberg MT, Kounatidis I, Christensen D, Kostov M, Kimber S, Roberts I, Ligoxygakis P: Pathogen and host factors are needed to provoke a systemic host response to gastrointestinal infection of Drosophila larvae by Candida albicans. Dis Model Mech. 2011 Jul;4(4):515-25. doi: 10.1242/dmm.006627. Epub 2011 May 2. [PubMed:21540243 ]