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Showing Protein Candidapepsin-9 (HMDBP14608)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14608
Secondary Accession Numbers None
Name Candidapepsin-9
Synonyms
  1. ACP 9
  2. Aspartate protease 9
  3. Secreted aspartic protease 9
Gene Name SAP9
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Involved in triggering host polymorphonuclear neutrophils chemotaxis toward germ tubes. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein. Required for cell surface integrity and cell separation during budding.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
adhesion of symbiont to host
modulation by symbiont of host cell-mediated immune response
proteolysis
pathogenesis
fungal-type cell wall organization
Cellular Component
cell surface
anchored to membrane
extracellular region
fungal-type cell wall
extracellular vesicle
anchored to plasma membrane
integral to membrane
Molecular Function
aspartic-type endopeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 544
Molecular Weight 58482.715
Theoretical pI 5.244
Pfam Domain Function
Signals
  • 1-17;
Transmembrane Regions
  • 524-544;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q59SU1
UniProtKB/Swiss-Prot Entry Name CARP9_CANAL
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. doi: 10.1073/pnas.0401648101. Epub 2004 May 3. [PubMed:15123810 ]
  2. van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT: Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52. [PubMed:17419877 ]
  3. Muzzey D, Schwartz K, Weissman JS, Sherlock G: Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97. [PubMed:24025428 ]
  4. Sorgo AG, Heilmann CJ, Dekker HL, Bekker M, Brul S, de Koster CG, de Koning LJ, Klis FM: Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans. Eukaryot Cell. 2011 Aug;10(8):1071-81. doi: 10.1128/EC.05011-11. Epub 2011 May 27. [PubMed:21622905 ]
  5. Aoki W, Kitahara N, Miura N, Morisaka H, Yamamoto Y, Kuroda K, Ueda M: Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans. J Biochem. 2011 Oct;150(4):431-8. doi: 10.1093/jb/mvr073. Epub 2011 Jun 5. [PubMed:21646240 ]
  6. Bochenska O, Rapala-Kozik M, Wolak N, Bras G, Kozik A, Dubin A, Aoki W, Ueda M, Mak P: Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin. Peptides. 2013 Oct;48:49-58. doi: 10.1016/j.peptides.2013.07.023. Epub 2013 Aug 6. [PubMed:23927842 ]
  7. Copping VM, Barelle CJ, Hube B, Gow NA, Brown AJ, Odds FC: Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes. J Antimicrob Chemother. 2005 May;55(5):645-54. doi: 10.1093/jac/dki088. Epub 2005 Apr 8. [PubMed:15820985 ]
  8. Monod M, Hube B, Hess D, Sanglard D: Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans. Microbiology (Reading). 1998 Oct;144 ( Pt 10):2731-2737. doi: 10.1099/00221287-144-10-2731. [PubMed:9802014 ]
  9. Albrecht A, Felk A, Pichova I, Naglik JR, Schaller M, de Groot P, Maccallum D, Odds FC, Schafer W, Klis F, Monod M, Hube B: Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. J Biol Chem. 2006 Jan 13;281(2):688-94. doi: 10.1074/jbc.M509297200. Epub 2005 Nov 3. [PubMed:16269404 ]
  10. Hornbach A, Heyken A, Schild L, Hube B, Loffler J, Kurzai O: The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils. Infect Immun. 2009 Dec;77(12):5216-24. doi: 10.1128/IAI.00723-09. Epub 2009 Oct 5. [PubMed:19805528 ]