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Identification
HMDB Protein ID HMDBP14610
Secondary Accession Numbers None
Name Exendin-1
Synonyms
  1. Helospectin-1
  2. VIP-like 1
Gene Name Not Available
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function O-linked and free exendin-1 and exendin-1b have vasoactive intestinal peptide(VIP)/secretin-like biological activities. They interact with rat and human VIP receptors 1 (VIPR1) and 2 (VIPR2), with the highest affinity for the human VIPR2. They induce hypotension that is mediated by relaxation of cardiac smooth muscle.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of blood pressure
Cellular Component
extracellular region
Molecular Function
toxin activity
hormone activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 4095.545
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P0DJ94
UniProtKB/Swiss-Prot Entry Name EXE1_HELHO
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Fry BG, Roelants K, Winter K, Hodgson WC, Griesman L, Kwok HF, Scanlon D, Karas J, Shaw C, Wong L, Norman JA: Novel venom proteins produced by differential domain-expression strategies in beaded lizards and gila monsters (genus Heloderma). Mol Biol Evol. 2010 Feb;27(2):395-407. doi: 10.1093/molbev/msp251. Epub 2009 Oct 15. [PubMed:19837656 ]
  2. Vandermeers-Piret MC, Vandermeers A, Gourlet P, Ali MH, Waelbroeck M, Robberecht P: Evidence that the lizard helospectin peptides are O-glycosylated. Eur J Biochem. 2000 Jul;267(14):4556-60. doi: 10.1046/j.1432-1327.2000.01506.x. [PubMed:10880980 ]
  3. Gourlet P, Vandermeers A, Van Rampelbergh J, De Neef P, Cnudde J, Waelbroeck M, Robberecht P: Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52. doi: 10.1111/j.1749-6632.1998.tb11184.x. [PubMed:9928018 ]
  4. Tsueshita T, Onyukusel H, Sethi V, Gandhi S, Rubinstein I: Helospectin I and II evoke vasodilation in the intact peripheral microcirculation. Peptides. 2004 Jan;25(1):65-9. doi: 10.1016/j.peptides.2003.11.010. [PubMed:15003357 ]