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Identification |
HMDB Protein ID
| HMDBP14610 |
Secondary Accession Numbers
| None |
Name
| Exendin-1 |
Synonyms
|
- Helospectin-1
- VIP-like 1
|
Gene Name
| Not Available |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| O-linked and free exendin-1 and exendin-1b have vasoactive intestinal peptide(VIP)/secretin-like biological activities. They interact with rat and human VIP receptors 1 (VIPR1) and 2 (VIPR2), with the highest affinity for the human VIPR2. They induce hypotension that is mediated by relaxation of cardiac smooth muscle. |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
regulation of blood pressure |
Cellular Component |
extracellular region |
Molecular Function |
toxin activity |
hormone activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 4095.545 |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P0DJ94 |
UniProtKB/Swiss-Prot Entry Name
| EXE1_HELHO |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Fry BG, Roelants K, Winter K, Hodgson WC, Griesman L, Kwok HF, Scanlon D, Karas J, Shaw C, Wong L, Norman JA: Novel venom proteins produced by differential domain-expression strategies in beaded lizards and gila monsters (genus Heloderma). Mol Biol Evol. 2010 Feb;27(2):395-407. doi: 10.1093/molbev/msp251. Epub 2009 Oct 15. [PubMed:19837656 ]
- Vandermeers-Piret MC, Vandermeers A, Gourlet P, Ali MH, Waelbroeck M, Robberecht P: Evidence that the lizard helospectin peptides are O-glycosylated. Eur J Biochem. 2000 Jul;267(14):4556-60. doi: 10.1046/j.1432-1327.2000.01506.x. [PubMed:10880980 ]
- Gourlet P, Vandermeers A, Van Rampelbergh J, De Neef P, Cnudde J, Waelbroeck M, Robberecht P: Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52. doi: 10.1111/j.1749-6632.1998.tb11184.x. [PubMed:9928018 ]
- Tsueshita T, Onyukusel H, Sethi V, Gandhi S, Rubinstein I: Helospectin I and II evoke vasodilation in the intact peripheral microcirculation. Peptides. 2004 Jan;25(1):65-9. doi: 10.1016/j.peptides.2003.11.010. [PubMed:15003357 ]
|