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Showing Protein Pro-MCH (HMDBP14614)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14614
Secondary Accession Numbers None
Name Pro-MCH
Synonyms Not Available
Gene Name PMCH
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function MCH inhibits ACTH secretion at the end of the light on period which corresponds to the peak of the circadian rhythm in ACTH. Inhibits also stress induced ACTH release during the light off period of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array of neuronal functions. Stimulates sexual behavior when injected into the ventromedial nucleus, this effect is antagonized by NEI. In the medial preoptic area, stimulates anxiety and sexual behavior. Antagonizes inhibitory effect of melanotropin alpha on exploration behavior.NEI can influence differentiation of neuronal processes in brain neurons. Affects the content of neurofilament protein in neuritogenesis (in vitro). May also be a neuromodulatory factor. In behavioral tests, it stimulates exploration and anxiety when injected into the ventromedial nucleus. Also stimulates grooming, locomotion and rearing. May antagonize the inhibitory effect of mch on ACTH release. Reduces dopamine and dopac release in the ventromedial nucleus.
Pathways
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
negative regulation of synaptic transmission, dopaminergic
learning or memory
elevation of cytosolic calcium ion concentration
negative regulation of blood pressure
drinking behavior
neuropeptide signaling pathway
positive regulation of circadian sleep/wake cycle, REM sleep
regulation of neuronal synaptic plasticity
feeding behavior
glucose homeostasis
lactation
response to cold
synaptic transmission
regulation of heart rate
Cellular Component
nucleus
synapse
extracellular space
Molecular Function
melanin-concentrating hormone activity
type 1 melanin-concentrating hormone receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 165
Molecular Weight 18481.93
Theoretical pI 7.286
Pfam Domain Function
Signals
  • 1-21;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P14200
UniProtKB/Swiss-Prot Entry Name MCH_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Nahon JL, Presse F, Bittencourt JC, Sawchenko PE, Vale W: The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Endocrinology. 1989 Oct;125(4):2056-65. doi: 10.1210/endo-125-4-2056. [PubMed:2477226 ]
  2. Thompson RC, Watson SJ: Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene. DNA Cell Biol. 1990 Nov;9(9):637-45. doi: 10.1089/dna.1990.9.637. [PubMed:2261081 ]
  3. Vaughan JM, Fischer WH, Hoeger C, Rivier J, Vale W: Characterization of melanin-concentrating hormone from rat hypothalamus. Endocrinology. 1989 Sep;125(3):1660-5. doi: 10.1210/endo-125-3-1660. [PubMed:2759038 ]
  4. Hervieu G, Nahon JL: Pro-melanin concentrating hormone messenger ribonucleic acid and peptides expression in peripheral tissues of the rat. Neuroendocrinology. 1995 Apr;61(4):348-64. doi: 10.1159/000126857. [PubMed:7783849 ]
  5. Hervieu G, Volant K, Grishina O, Descroix-Vagne M, Nahon JL: Similarities in cellular expression and functions of melanin-concentrating hormone and atrial natriuretic factor in the rat digestive tract. Endocrinology. 1996 Feb;137(2):561-71. doi: 10.1210/endo.137.2.8593803. [PubMed:8593803 ]
  6. Takahashi K, Suzuki H, Totsune K, Murakami O, Satoh F, Sone M, Sasano H, Mouri T, Shibahara S: Melanin-concentrating hormone in human and rat. Neuroendocrinology. 1995 May;61(5):493-8. doi: 10.1159/000126872. [PubMed:7617126 ]
  7. Parkes D, Vale W: Secretion of melanin-concentrating hormone and neuropeptide-EI from cultured rat hypothalamic cells. Endocrinology. 1992 Oct;131(4):1826-31. doi: 10.1210/endo.131.4.1327720. [PubMed:1327720 ]
  8. Viale A, Ortola C, Hervieu G, Furuta M, Barbero P, Steiner DF, Seidah NG, Nahon JL: Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. J Biol Chem. 1999 Mar 5;274(10):6536-45. doi: 10.1074/jbc.274.10.6536. [PubMed:10037747 ]
  9. Bluet-Pajot MT, Presse F, Voko Z, Hoeger C, Mounier F, Epelbaum J, Nahon JL: Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat. J Neuroendocrinol. 1995 Apr;7(4):297-303. doi: 10.1111/j.1365-2826.1995.tb00761.x. [PubMed:7647772 ]
  10. Gonzalez MI, Baker BI, Hole DR, Wilson CA: Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with alpha-MSH, MCH and dopamine. Peptides. 1998;19(6):1007-16. doi: 10.1016/s0196-9781(98)00045-x. [PubMed:9700748 ]
  11. Kistler-Heer V, Schlumpf M, Lichtensteiger W: Melanocortin and MCH precursor-derived NEI effects on striatum-midbrain co-cultures. Peptides. 1998;19(8):1317-27. doi: 10.1016/s0196-9781(98)00076-x. [PubMed:9809645 ]