Hmdb loader
Identification
HMDB Protein ID HMDBP14624
Secondary Accession Numbers None
Name Afamin
Synonyms
  1. Alpha-albumin
  2. Alpha-Alb
Gene Name AFM
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Functions as carrier for hydrophobic molecules in body fluids. Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
protein stabilization
protein transport within extracellular region
vitamin transport
Cellular Component
cytoplasm
extracellular space
Molecular Function
fatty acid binding
zinc ion binding
vitamin E binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 608
Molecular Weight 69378.415
Theoretical pI 5.781
Pfam Domain Function
Signals
  • 1-21;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O89020
UniProtKB/Swiss-Prot Entry Name AFAM_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  5. Ghesquiere B, Van Damme J, Martens L, Vandekerckhove J, Gevaert K: Proteome-wide characterization of N-glycosylation events by diagonal chromatography. J Proteome Res. 2006 Sep;5(9):2438-47. doi: 10.1021/pr060186m. [PubMed:16944957 ]
  6. Bernhard OK, Kapp EA, Simpson RJ: Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. J Proteome Res. 2007 Mar;6(3):987-95. doi: 10.1021/pr0604559. [PubMed:17330941 ]
  7. Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W: Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier. J Neurochem. 2009 Feb;108(3):707-18. doi: 10.1111/j.1471-4159.2008.05796.x. Epub 2008 Nov 27. [PubMed:19046407 ]
  8. Mihara E, Hirai H, Yamamoto H, Tamura-Kawakami K, Matano M, Kikuchi A, Sato T, Takagi J: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin. Elife. 2016 Feb 23;5. doi: 10.7554/eLife.11621. [PubMed:26902720 ]